Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
GTPase HRas (Homo sapiens (Human)) | BDBM50520327 (CHEMBL4456044) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | n/a | 51 | n/a | n/a | n/a | n/a | n/a |
Frontier Medicines Curated by ChEMBL | Assay Description Inhibition GST-tagged recombinant HRAS G12V mutant (1 to 166 amino acids) (unknown origin) expressed in Escherichia coli C41(DE3) by SPR assay | J Med Chem 63: 4430-4444 (2020) Article DOI: 10.1021/acs.jmedchem.9b01581 BindingDB Entry DOI: 10.7270/Q2ZG6WM7 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |