Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
GTPase KRas (Homo sapiens (Human)) | BDBM50579095 (CHEMBL4851139) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 690 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of His6-tagged KRas G12V mutant (unknown origin) expressed in Escherichia coli BL21(DE3) cells assessed as reduction in Ras/GST-fused Raf ... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01130 BindingDB Entry DOI: 10.7270/Q22V2KZ6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GTPase KRas (Homo sapiens (Human)) | BDBM50579095 (CHEMBL4851139) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of KRas signaling in EGF-stimulated human NCI-H358 cells assessed as reduction in Akt phosphorylation at thr308 residue preincubated for 4... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01130 BindingDB Entry DOI: 10.7270/Q22V2KZ6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GTPase KRas (Homo sapiens (Human)) | BDBM50579095 (CHEMBL4851139) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of KRas signaling in EGF-stimulated human NCI-H358 cells assessed as reduction in Akt phosphorylation at ser473 residue preincubated for 4... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01130 BindingDB Entry DOI: 10.7270/Q22V2KZ6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GTPase KRas (Homo sapiens (Human)) | BDBM50579095 (CHEMBL4851139) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of KRas signaling in EGF-stimulated human NCI-H358 cells assessed as reduction in MEK phosphorylation preincubated for 4 hrs followed by E... | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01130 BindingDB Entry DOI: 10.7270/Q22V2KZ6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GTPase KRas (Homo sapiens (Human)) | BDBM50579095 (CHEMBL4851139) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding affinity to GppNHp bound His6-tagged KRas G12V mutant (unknown origin) incubated for 1 hr by fluorescence polarization | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01130 BindingDB Entry DOI: 10.7270/Q22V2KZ6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GTPase KRas (Homo sapiens (Human)) | BDBM50579095 (CHEMBL4851139) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding affinity to GTPgammaS bound His6-tagged KRas G12V mutant (unknown origin) incubated for 1 hr by fluorescence polarization | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01130 BindingDB Entry DOI: 10.7270/Q22V2KZ6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
GTPase KRas (Homo sapiens (Human)) | BDBM50579095 (CHEMBL4851139) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Binding affinity to GDP bound His6-tagged KRas G12V mutant (unknown origin) incubated for 1 hr by fluorescence polarization | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01130 BindingDB Entry DOI: 10.7270/Q22V2KZ6 | |||||||||||
More data for this Ligand-Target Pair |