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Found 1 hit Enz. Inhib. hit(s) with Target = 'Gag-Pol polyprotein [600-1027,R876K]/[600-1155]' and Ligand = 'BDBM2085'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Gag-Pol polyprotein [600-1027,R876K]/[600-1155]


(Human immunodeficiency virus type 1)		BDBM2085
PNG
(2-ethyl-9-methyl-13-[2-(4-methylphenyl)ethyl]-2,4,...)
Show SMILES CCN1c2ncccc2N(C)C(=O)c2cc(CCc3ccc(C)cc3)cnc12
Show InChI InChI=1S/C23H24N4O/c1-4-27-21-19(23(28)26(3)20-6-5-13-24-22(20)27)14-18(15-25-21)12-11-17-9-7-16(2)8-10-17/h5-10,13-15H,4,11-12H2,1-3H3
PDB
MMDB

UniProtKB/SwissProt

B.MOAD
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PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 100n/an/an/an/an/an/a



Boehringer Ingelheim Pharmaceuticals Inc.



Assay Description
The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.

J Med Chem 41: 2960-71 (1998)


Article DOI: 10.1021/jm9707028
BindingDB Entry DOI: 10.7270/Q28W3BH2
More data for this
Ligand-Target Pair