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Found 1 hit Enz. Inhib. hit(s) with Target = 'Gamma-aminobutyric acid receptor subunit alpha-6/beta-3' and Ligand = 'BDBM50457438'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Gamma-aminobutyric acid receptor subunit alpha-6/beta-3


(RAT-Rattus norvegicus)		BDBM50457438
PNG
(CHEMBL4208971)
Show SMILES CCCCOc1ccc(cc1)C(=O)Nc1c(nc2ccc(Br)cn12)-c1cccs1
Show InChI InChI=1S/C22H20BrN3O2S/c1-2-3-12-28-17-9-6-15(7-10-17)22(27)25-21-20(18-5-4-13-29-18)24-19-11-8-16(23)14-26(19)21/h4-11,13-14H,2-3,12H2,1H3,(H,25,27)
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 4.07E+3n/an/an/an/an/an/a



Johannes Gutenberg University Mainz

Curated by ChEMBL


Assay Description
Displacement of [3H]EBOB from rat GABA-A receptor alpha6beta3 expressed in HEK293 cell membranes after 90 mins in presence of GABA by liquid scintill...

J Med Chem 61: 1951-1968 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01484
BindingDB Entry DOI: 10.7270/Q2P271Q0
More data for this
Ligand-Target Pair