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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2' and Ligand = 'BDBM50125677'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Gamma-secretase subunit APH-1A/Gamma-secretase subunit APH-1B/Gamma-secretase subunit PEN-2/Nicastrin/Presenilin-1/Presenilin-2


(Homo sapiens (Human))		BDBM50125677
PNG
((S)-4-Methyl-2-phenylacetylamino-pentanoic acid ((...)
Show SMILES CCCC(=O)[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](CC(C)C)NC(=O)Cc1ccccc1
Show InChI InChI=1S/C27H42N2O4/c1-4-11-24(30)26(32)22(17-20-12-7-5-8-13-20)29-27(33)23(16-19(2)3)28-25(31)18-21-14-9-6-10-15-21/h6,9-10,14-15,19-20,22-23,26,32H,4-5,7-8,11-13,16-18H2,1-3H3,(H,28,31)(H,29,33)/t22-,23-,26+/m0/s1
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KEGG

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n/an/a 600n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of amyloid beta protein production in transfected H4 (neuroglioma) cells expressing APF constructs.

Bioorg Med Chem Lett 13: 1203-6 (2003)


BindingDB Entry DOI: 10.7270/Q279442Z
More data for this
Ligand-Target Pair