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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Genome polyprotein' and Ligand = 'BDBM12282'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Genome polyprotein


(Hepatitis C virus (HCV genotype 1a, isolate H))		BDBM12282
PNG
(1,1-Dimethylethyl-[2-[(1R,5S)-2(S)-[[(3-amino-1-et...)
Show SMILES CCC(NC(=O)[C@@H]1[C@@H]2[C@H](CN1C(=O)[C@@H](NC(=O)OC(C)(C)C)C1CCCCC1)C2(C)C)C(=O)C(N)=O |r|
Show InChI InChI=1S/C26H42N4O6/c1-7-16(20(31)21(27)32)28-22(33)19-17-15(26(17,5)6)13-30(19)23(34)18(14-11-9-8-10-12-14)29-24(35)36-25(2,3)4/h14-19H,7-13H2,1-6H3,(H2,27,32)(H,28,33)(H,29,35)/t15-,16?,17-,18-,19-/m0/s1
PDB
MMDB

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PC cid
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Similars
Article
PubMed
 740n/an/an/an/an/an/an/an/a



Schering-Plough Research Institute



Assay Description
Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...

J Med Chem 49: 6074-86 (2006)


Article DOI: 10.1021/jm060325b
BindingDB Entry DOI: 10.7270/Q2DF6PF6
More data for this
Ligand-Target Pair