Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha' and Ligand = 'BDBM14418'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha (Bos taurus (bovine))	BDBM14418 (3-(3-chlorophenyl)-5-[hydroxy(4-iodophenyl)(1-meth...) Show SMILES Cn1cncc1C(O)(c1ccc(I)cc1)c1ccc2n(C)c(=O)n(-c3cccc(Cl)c3)c2c1 Show InChI InChI=1S/C25H20ClIN4O2/c1-29-15-28-14-23(29)25(33,16-6-9-19(27)10-7-16)17-8-11-21-22(12-17)31(24(32)30(21)2)20-5-3-4-18(26)13-20/h3-15,33H,1-2H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories					Assay Description The in vitro activity of compounds inhibiting GGTase-1 was determined by measuring the transfer of [3H]-geranylgeranylpyrophosphate to substrate Ha-R...				Bioorg Med Chem Lett 15: 2918-22 (2005) Article DOI: 10.1016/j.bmcl.2005.03.049 BindingDB Entry DOI: 10.7270/Q27942XB
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