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Found 1 hit Enz. Inhib. hit(s) with Target = 'Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha' and Ligand = 'BDBM14438'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha


(Bos taurus (bovine))		BDBM14438
PNG
(2-quinolone analog 2d | N-{[4-(3-chlorophenyl)-1-m...)
Show SMILES Cn1c2ccc(cc2c(cc1=O)-c1cccc(Cl)c1)C(NC=O)c1cncn1Cc1ccc(cc1)C#N
Show InChI InChI=1S/C29H22ClN5O2/c1-34-26-10-9-22(12-25(26)24(13-28(34)37)21-3-2-4-23(30)11-21)29(33-18-36)27-15-32-17-35(27)16-20-7-5-19(14-31)6-8-20/h2-13,15,17-18,29H,16H2,1H3,(H,33,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
KEGG
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a>1.00E+4n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The in vitro activity of compounds inhibiting GGTase-1 was determined by measuring the transfer of [3H]-geranylgeranylpyrophosphate to substrate Ha-R...

Bioorg Med Chem Lett 15: 2033-9 (2005)


Article DOI: 10.1016/j.bmcl.2005.02.062
BindingDB Entry DOI: 10.7270/Q23J3B61
More data for this
Ligand-Target Pair