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Found 1 hit Enz. Inhib. hit(s) with Target = 'Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha' and Ligand = 'BDBM17333'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha


(Bos taurus (bovine))		BDBM17333
PNG
(1-[(2R)-2-{[(4-cyanophenyl)methyl]amino}-3-(1-meth...)
Show SMILES Cn1cncc1C[C@@H](NCc1ccc(cc1)C#N)C(=O)N1CCC(C#N)=C(C1)c1cccc2ccccc12 |r,c:27|
Show InChI InChI=1S/C31H28N6O/c1-36-21-34-19-26(36)15-30(35-18-23-11-9-22(16-32)10-12-23)31(38)37-14-13-25(17-33)29(20-37)28-8-4-6-24-5-2-3-7-27(24)28/h2-12,19,21,30,35H,13-15,18,20H2,1H3/t30-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars
Article
PubMed
n/an/a 3.50E+3n/an/an/an/a7.537



Abbott Laboratories



Assay Description
The in vitro activity of compounds inhibiting GGTase-1 was determined by measuring the transfer of [3H]-geranylgeranylpyrophosphate to substrate Ha-R...

Bioorg Med Chem Lett 13: 1359-62 (2003)


Article DOI: 10.1016/S0960-894X(03)00095-7
BindingDB Entry DOI: 10.7270/Q2QJ7FK9
More data for this
Ligand-Target Pair