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Found 1 hit Enz. Inhib. hit(s) with Target = 'Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha' and Ligand = 'BDBM50100311'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50100311
PNG
(2-(3,4-Dichloro-phenoxy)-4-imidazol-1-ylmethyl-ben...)
Show SMILES Clc1ccc(Oc2cc(Cn3ccnc3)ccc2C#N)cc1Cl
Show InChI InChI=1S/C17H11Cl2N3O/c18-15-4-3-14(8-16(15)19)23-17-7-12(1-2-13(17)9-20)10-22-6-5-21-11-22/h1-8,11H,10H2
PDB

KEGG

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PubMed
n/an/a 1.20E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-tran...

Bioorg Med Chem Lett 11: 1257-60 (2001)


BindingDB Entry DOI: 10.7270/Q2FX78RS
More data for this
Ligand-Target Pair