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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha' and Ligand = 'BDBM50112377'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50112377
PNG
(1-(3-Chloro-phenyl)-4-[3-(4'-trifluoromethyl-biphe...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1ccc(Cn2cncc2CN2CCN(C(=O)C2)c2cccc(Cl)c2)cc1
Show InChI InChI=1S/C28H24ClF3N4O/c29-24-2-1-3-25(14-24)36-13-12-34(18-27(36)37)17-26-15-33-19-35(26)16-20-4-6-21(7-5-20)22-8-10-23(11-9-22)28(30,31)32/h1-11,14-15,19H,12-13,16-18H2
PDB

KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 140n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of the human Geranylgeranyl transferase type I catalyzed incorporation of [3H]-GGPP into a biotinylated peptide corresponding to the C-ter...

Bioorg Med Chem Lett 12: 1269-73 (2002)


BindingDB Entry DOI: 10.7270/Q2T72GSB
More data for this
Ligand-Target Pair