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Found 1 hit Enz. Inhib. hit(s) with Target = 'Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha' and Ligand = 'BDBM50153177'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50153177
PNG
(CHEMBL187809 | N-[3-(4-Cyano-benzyl)-3H-imidazol-4...)
Show SMILES CCOc1cccc(c1)-c1cc(ccc1CN(Cc1cncn1Cc1ccc(cc1)C#N)S(C)(=O)=O)C#N
Show InChI InChI=1S/C29H27N5O3S/c1-3-37-28-6-4-5-25(14-28)29-13-24(16-31)11-12-26(29)19-34(38(2,35)36)20-27-17-32-21-33(27)18-23-9-7-22(15-30)8-10-23/h4-14,17,21H,3,18-20H2,1-2H3
PDB

KEGG

UniProtKB/SwissProt

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CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.00E+4n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of [3H]-GGPP incorporation into C-terminus of K-Ras by human Geranylgeranyl transferase type I

Bioorg Med Chem Lett 14: 5057-62 (2004)


Article DOI: 10.1016/j.bmcl.2004.07.083
BindingDB Entry DOI: 10.7270/Q2N0160C
More data for this
Ligand-Target Pair