Found 2 hits Enz. Inhib. hit(s) with Target = 'Glucagon receptor' and Ligand = 'BDBM50007238' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Glucagon receptor
(Homo sapiens (Human)) | BDBM50007238
(CHEMBL3238225)Show SMILES COc1ccc(cc1)C1=N[C@@]2(CC[C@@H](CC2)C(C)(C)C)N([C@H](CCC(C)(C)C)c2ccc(cc2)C(=O)NCc2nn[nH]n2)C1=O |r,wU:13.17,21.23,wD:10.11,t:9,(13.4,-44.07,;11.86,-44.06,;11.08,-45.39,;11.84,-46.73,;11.06,-48.06,;9.52,-48.05,;8.76,-46.71,;9.54,-45.38,;8.75,-49.38,;7.2,-49.44,;6.79,-50.92,;5.6,-49.93,;4.15,-50.46,;3.89,-51.98,;5.08,-52.96,;6.52,-52.43,;2.45,-52.51,;1.27,-51.53,;1,-53.04,;2.19,-54.03,;8.07,-51.78,;8.12,-53.31,;6.8,-54.1,;6.82,-55.64,;5.49,-56.42,;5.51,-57.96,;4.15,-55.67,;4.15,-57.18,;9.45,-54.1,;9.42,-55.64,;10.75,-56.43,;12.1,-55.67,;12.12,-54.14,;10.79,-53.35,;13.42,-56.47,;13.4,-58,;14.76,-55.71,;16.08,-56.5,;17.43,-55.74,;18.82,-56.38,;19.86,-55.25,;19.11,-53.9,;17.6,-54.21,;9.28,-50.82,;10.76,-51.24,)| Show InChI InChI=1S/C35H47N7O3/c1-33(2,3)19-18-28(23-8-10-25(11-9-23)31(43)36-22-29-38-40-41-39-29)42-32(44)30(24-12-14-27(45-7)15-13-24)37-35(42)20-16-26(17-21-35)34(4,5)6/h8-15,26,28H,16-22H2,1-7H3,(H,36,43)(H,38,39,40,41)/t26-,28-,35-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Displacement of [125I]-glucagon from recombinant human GCGR expressed in CHO cells after 60 mins by scintillation counting analysis |
J Med Chem 57: 2601-10 (2014)
Article DOI: 10.1021/jm401858f
BindingDB Entry DOI: 10.7270/Q20V8F9P |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Homo sapiens (Human)) | BDBM50007238
(CHEMBL3238225)Show SMILES COc1ccc(cc1)C1=N[C@@]2(CC[C@@H](CC2)C(C)(C)C)N([C@H](CCC(C)(C)C)c2ccc(cc2)C(=O)NCc2nn[nH]n2)C1=O |r,wU:13.17,21.23,wD:10.11,t:9,(13.4,-44.07,;11.86,-44.06,;11.08,-45.39,;11.84,-46.73,;11.06,-48.06,;9.52,-48.05,;8.76,-46.71,;9.54,-45.38,;8.75,-49.38,;7.2,-49.44,;6.79,-50.92,;5.6,-49.93,;4.15,-50.46,;3.89,-51.98,;5.08,-52.96,;6.52,-52.43,;2.45,-52.51,;1.27,-51.53,;1,-53.04,;2.19,-54.03,;8.07,-51.78,;8.12,-53.31,;6.8,-54.1,;6.82,-55.64,;5.49,-56.42,;5.51,-57.96,;4.15,-55.67,;4.15,-57.18,;9.45,-54.1,;9.42,-55.64,;10.75,-56.43,;12.1,-55.67,;12.12,-54.14,;10.79,-53.35,;13.42,-56.47,;13.4,-58,;14.76,-55.71,;16.08,-56.5,;17.43,-55.74,;18.82,-56.38,;19.86,-55.25,;19.11,-53.9,;17.6,-54.21,;9.28,-50.82,;10.76,-51.24,)| Show InChI InChI=1S/C35H47N7O3/c1-33(2,3)19-18-28(23-8-10-25(11-9-23)31(43)36-22-29-38-40-41-39-29)42-32(44)30(24-12-14-27(45-7)15-13-24)37-35(42)20-16-26(17-21-35)34(4,5)6/h8-15,26,28H,16-22H2,1-7H3,(H,36,43)(H,38,39,40,41)/t26-,28-,35-/m1/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 360 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck Research Laboratories
Curated by ChEMBL
| Assay Description
Antagonist activity at human GCGR expressed in CHO cells assessed as inhibition of glucagon-stimulated cAMP production preincubated for 30 mins follo... |
J Med Chem 57: 2601-10 (2014)
Article DOI: 10.1021/jm401858f
BindingDB Entry DOI: 10.7270/Q20V8F9P |
More data for this
Ligand-Target Pair | |
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