Found 3 hits Enz. Inhib. hit(s) with Target = 'Glucagon-like peptide 1 receptor' and Ligand = 'BDBM50121536' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50121536
(CHEMBL3616717)Show SMILES CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)C(O)=O |r| Show InChI InChI=1S/C185H289N45O57/c1-19-21-22-23-24-25-26-27-28-29-30-31-38-54-139(239)209-126(181(281)282)60-65-138(238)194-72-74-284-76-79-287-98-144(244)195-73-75-285-77-78-286-97-143(243)193-69-42-41-51-121(164(264)212-125(63-68-147(249)250)165(265)217-130(82-110-45-34-32-35-46-110)170(270)228-152(104(11)20-2)178(278)206-107(14)157(257)214-132(85-113-88-198-118-50-40-39-49-116(113)118)168(268)216-128(81-101(5)6)169(269)226-150(102(7)8)176(276)213-120(53-44-71-197-184(190)191)160(260)199-90-140(240)207-119(52-43-70-196-183(188)189)159(259)202-93-149(253)254)210-156(256)106(13)204-155(255)105(12)205-163(263)124(59-64-137(187)237)208-141(241)91-200-161(261)122(61-66-145(245)246)211-166(266)127(80-100(3)4)215-167(267)129(84-112-55-57-115(236)58-56-112)218-173(273)134(94-231)221-175(275)136(96-233)222-177(277)151(103(9)10)227-172(272)133(87-148(251)252)219-174(274)135(95-232)223-180(280)154(109(16)235)229-171(271)131(83-111-47-36-33-37-48-111)220-179(279)153(108(15)234)225-142(242)92-201-162(262)123(62-67-146(247)248)224-182(283)185(17,18)230-158(258)117(186)86-114-89-192-99-203-114/h32-37,39-40,45-50,55-58,88-89,99-109,117,119-136,150-154,198,231-236H,19-31,38,41-44,51-54,59-87,90-98,186H2,1-18H3,(H2,187,237)(H,192,203)(H,193,243)(H,194,238)(H,195,244)(H,199,260)(H,200,261)(H,201,262)(H,202,259)(H,204,255)(H,205,263)(H,206,278)(H,207,240)(H,208,241)(H,209,239)(H,210,256)(H,211,266)(H,212,264)(H,213,276)(H,214,257)(H,215,267)(H,216,268)(H,217,265)(H,218,273)(H,219,274)(H,220,279)(H,221,275)(H,222,277)(H,223,280)(H,224,283)(H,225,242)(H,226,269)(H,227,272)(H,228,270)(H,229,271)(H,230,258)(H,245,246)(H,247,248)(H,249,250)(H,251,252)(H,253,254)(H,281,282)(H4,188,189,196)(H4,190,191,197)/t104-,105-,106-,107-,108+,109+,117-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,150-,151-,152-,153-,154-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 0.190 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in absence of human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726 BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50121536
(CHEMBL3616717)Show SMILES CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)C(O)=O |r| Show InChI InChI=1S/C185H289N45O57/c1-19-21-22-23-24-25-26-27-28-29-30-31-38-54-139(239)209-126(181(281)282)60-65-138(238)194-72-74-284-76-79-287-98-144(244)195-73-75-285-77-78-286-97-143(243)193-69-42-41-51-121(164(264)212-125(63-68-147(249)250)165(265)217-130(82-110-45-34-32-35-46-110)170(270)228-152(104(11)20-2)178(278)206-107(14)157(257)214-132(85-113-88-198-118-50-40-39-49-116(113)118)168(268)216-128(81-101(5)6)169(269)226-150(102(7)8)176(276)213-120(53-44-71-197-184(190)191)160(260)199-90-140(240)207-119(52-43-70-196-183(188)189)159(259)202-93-149(253)254)210-156(256)106(13)204-155(255)105(12)205-163(263)124(59-64-137(187)237)208-141(241)91-200-161(261)122(61-66-145(245)246)211-166(266)127(80-100(3)4)215-167(267)129(84-112-55-57-115(236)58-56-112)218-173(273)134(94-231)221-175(275)136(96-233)222-177(277)151(103(9)10)227-172(272)133(87-148(251)252)219-174(274)135(95-232)223-180(280)154(109(16)235)229-171(271)131(83-111-47-36-33-37-48-111)220-179(279)153(108(15)234)225-142(242)92-201-162(262)123(62-67-146(247)248)224-182(283)185(17,18)230-158(258)117(186)86-114-89-192-99-203-114/h32-37,39-40,45-50,55-58,88-89,99-109,117,119-136,150-154,198,231-236H,19-31,38,41-44,51-54,59-87,90-98,186H2,1-18H3,(H2,187,237)(H,192,203)(H,193,243)(H,194,238)(H,195,244)(H,199,260)(H,200,261)(H,201,262)(H,202,259)(H,204,255)(H,205,263)(H,206,278)(H,207,240)(H,208,241)(H,209,239)(H,210,256)(H,211,266)(H,212,264)(H,213,276)(H,214,257)(H,215,267)(H,216,268)(H,217,265)(H,218,273)(H,219,274)(H,220,279)(H,221,275)(H,222,277)(H,223,280)(H,224,283)(H,225,242)(H,226,269)(H,227,272)(H,228,270)(H,229,271)(H,230,258)(H,245,246)(H,247,248)(H,249,250)(H,251,252)(H,253,254)(H,281,282)(H4,188,189,196)(H4,190,191,197)/t104-,105-,106-,107-,108+,109+,117-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,150-,151-,152-,153-,154-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Displacement of [125I]-GLP1 from human GLP1 receptor expressed in BHK cells after 2 hrs in presence of 2% human serum albumin |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726 BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this Ligand-Target Pair | |
Glucagon-like peptide 1 receptor
(Homo sapiens (Human)) | BDBM50121536
(CHEMBL3616717)Show SMILES CCCCCCCCCCCCCCCC(=O)N[C@@H](CCC(=O)NCCOCCOCC(=O)NCCOCCOCC(=O)NCCCC[C@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)C(C)(C)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)C(O)=O |r| Show InChI InChI=1S/C185H289N45O57/c1-19-21-22-23-24-25-26-27-28-29-30-31-38-54-139(239)209-126(181(281)282)60-65-138(238)194-72-74-284-76-79-287-98-144(244)195-73-75-285-77-78-286-97-143(243)193-69-42-41-51-121(164(264)212-125(63-68-147(249)250)165(265)217-130(82-110-45-34-32-35-46-110)170(270)228-152(104(11)20-2)178(278)206-107(14)157(257)214-132(85-113-88-198-118-50-40-39-49-116(113)118)168(268)216-128(81-101(5)6)169(269)226-150(102(7)8)176(276)213-120(53-44-71-197-184(190)191)160(260)199-90-140(240)207-119(52-43-70-196-183(188)189)159(259)202-93-149(253)254)210-156(256)106(13)204-155(255)105(12)205-163(263)124(59-64-137(187)237)208-141(241)91-200-161(261)122(61-66-145(245)246)211-166(266)127(80-100(3)4)215-167(267)129(84-112-55-57-115(236)58-56-112)218-173(273)134(94-231)221-175(275)136(96-233)222-177(277)151(103(9)10)227-172(272)133(87-148(251)252)219-174(274)135(95-232)223-180(280)154(109(16)235)229-171(271)131(83-111-47-36-33-37-48-111)220-179(279)153(108(15)234)225-142(242)92-201-162(262)123(62-67-146(247)248)224-182(283)185(17,18)230-158(258)117(186)86-114-89-192-99-203-114/h32-37,39-40,45-50,55-58,88-89,99-109,117,119-136,150-154,198,231-236H,19-31,38,41-44,51-54,59-87,90-98,186H2,1-18H3,(H2,187,237)(H,192,203)(H,193,243)(H,194,238)(H,195,244)(H,199,260)(H,200,261)(H,201,262)(H,202,259)(H,204,255)(H,205,263)(H,206,278)(H,207,240)(H,208,241)(H,209,239)(H,210,256)(H,211,266)(H,212,264)(H,213,276)(H,214,257)(H,215,267)(H,216,268)(H,217,265)(H,218,273)(H,219,274)(H,220,279)(H,221,275)(H,222,277)(H,223,280)(H,224,283)(H,225,242)(H,226,269)(H,227,272)(H,228,270)(H,229,271)(H,230,258)(H,245,246)(H,247,248)(H,249,250)(H,251,252)(H,253,254)(H,281,282)(H4,188,189,196)(H4,190,191,197)/t104-,105-,106-,107-,108+,109+,117-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,150-,151-,152-,153-,154-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 0.00300 | n/a | n/a | n/a | n/a |
Novo Nordisk A/S
Curated by ChEMBL
| Assay Description Agonist activity at human GLP1 receptor expressed in BHK cells after 3 hrs by CRE firefly luciferase reporter gene assay in absence of human serum al... |
J Med Chem 58: 7370-80 (2015)
Article DOI: 10.1021/acs.jmedchem.5b00726 BindingDB Entry DOI: 10.7270/Q2TX3H6D |
More data for this Ligand-Target Pair | |