Found 2 hits Enz. Inhib. hit(s) with Target = 'Glucocorticoid receptor' and Ligand = 'BDBM50402498' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50402498
(CHEMBL2204043)Show SMILES FC(F)(F)c1cccc(Cc2c([nH]c(=O)[nH]c2=O)[C@@H]2CC[C@@H](CC2)c2ccccc2)c1 |r,wU:18.18,21.25,(48.13,-27.4,;46.8,-26.63,;46.8,-25.09,;48.12,-25.84,;45.46,-27.39,;44.12,-26.61,;42.77,-27.37,;42.77,-28.91,;44.1,-29.69,;44.1,-31.25,;42.77,-32.04,;42.77,-33.59,;41.43,-34.36,;40.09,-33.59,;38.74,-34.38,;40.09,-32.04,;41.44,-31.27,;41.44,-29.73,;44.08,-34.36,;44.08,-35.9,;45.39,-36.68,;46.73,-35.92,;46.73,-34.38,;45.41,-33.59,;48.06,-36.7,;49.39,-35.93,;50.71,-36.71,;50.71,-38.25,;49.37,-39.01,;48.06,-38.23,;45.46,-28.94,)| Show InChI InChI=1S/C24H23F3N2O2/c25-24(26,27)19-8-4-5-15(13-19)14-20-21(28-23(31)29-22(20)30)18-11-9-17(10-12-18)16-6-2-1-3-7-16/h1-8,13,17-18H,9-12,14H2,(H2,28,29,30,31)/t17-,18+ | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Corcept Therapeutics
Curated by ChEMBL
| Assay Description Displacement of [3H]dexamethasone from human recombinant glucocorticoid receptor expressed in baculovirus after 18 hrs by scintillation counting anal... |
Bioorg Med Chem Lett 22: 7376-80 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.074 BindingDB Entry DOI: 10.7270/Q26111GW |
More data for this Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50402498
(CHEMBL2204043)Show SMILES FC(F)(F)c1cccc(Cc2c([nH]c(=O)[nH]c2=O)[C@@H]2CC[C@@H](CC2)c2ccccc2)c1 |r,wU:18.18,21.25,(48.13,-27.4,;46.8,-26.63,;46.8,-25.09,;48.12,-25.84,;45.46,-27.39,;44.12,-26.61,;42.77,-27.37,;42.77,-28.91,;44.1,-29.69,;44.1,-31.25,;42.77,-32.04,;42.77,-33.59,;41.43,-34.36,;40.09,-33.59,;38.74,-34.38,;40.09,-32.04,;41.44,-31.27,;41.44,-29.73,;44.08,-34.36,;44.08,-35.9,;45.39,-36.68,;46.73,-35.92,;46.73,-34.38,;45.41,-33.59,;48.06,-36.7,;49.39,-35.93,;50.71,-36.71,;50.71,-38.25,;49.37,-39.01,;48.06,-38.23,;45.46,-28.94,)| Show InChI InChI=1S/C24H23F3N2O2/c25-24(26,27)19-8-4-5-15(13-19)14-20-21(28-23(31)29-22(20)30)18-11-9-17(10-12-18)16-6-2-1-3-7-16/h1-8,13,17-18H,9-12,14H2,(H2,28,29,30,31)/t17-,18+ | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| 24 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Corcept Therapeutics
Curated by ChEMBL
| Assay Description Antagonist activity at glucocorticoid receptor in human SW1353 cells assessed as inhibition of dexamethasone-induced luciferase expression after 16 h... |
Bioorg Med Chem Lett 22: 7376-80 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.074 BindingDB Entry DOI: 10.7270/Q26111GW |
More data for this Ligand-Target Pair | |