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Found 2 hits Enz. Inhib. hit(s) with Target = 'Glucose-dependent insulinotropic receptor' and Ligand = 'BDBM50036658'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glucose-dependent insulinotropic receptor


(Mus musculus)
BDBM50036658
PNG
(CHEMBL3354789)
Show SMILES CCOC(=O)[C@@]1(Cc2ccccc2)CNc2cnc3c(cnn3c12)-c1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C25H21F3N4O2/c1-2-34-23(33)24(12-16-6-4-3-5-7-16)15-30-20-14-29-22-19(13-31-32(22)21(20)24)17-8-10-18(11-9-17)25(26,27)28/h3-11,13-14,30H,2,12,15H2,1H3/t24-/m0/s1
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Article
PubMed
n/an/an/an/a 25n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at mouse GPR119 overexpressed in CHO cells assessed as increase in cellular cAMP production by HTRF method


Bioorg Med Chem Lett 24: 5478-83 (2015)


Article DOI: 10.1016/j.bmcl.2014.10.010
BindingDB Entry DOI: 10.7270/Q29C7019
More data for this
Ligand-Target Pair
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))
BDBM50036658
PNG
(CHEMBL3354789)
Show SMILES CCOC(=O)[C@@]1(Cc2ccccc2)CNc2cnc3c(cnn3c12)-c1ccc(cc1)C(F)(F)F |r|
Show InChI InChI=1S/C25H21F3N4O2/c1-2-34-23(33)24(12-16-6-4-3-5-7-16)15-30-20-14-29-22-19(13-31-32(22)21(20)24)17-8-10-18(11-9-17)25(26,27)28/h3-11,13-14,30H,2,12,15H2,1H3/t24-/m0/s1
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UniProtKB/SwissProt

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GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/an/an/a 25n/an/an/an/a



Genomics Institute of the Novartis Research Foundation

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 overexpressed in CHO cells assessed as increase in cellular cAMP production by HTRF method


Bioorg Med Chem Lett 24: 5478-83 (2015)


Article DOI: 10.1016/j.bmcl.2014.10.010
BindingDB Entry DOI: 10.7270/Q29C7019
More data for this
Ligand-Target Pair