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Found 1 hit Enz. Inhib. hit(s) with Target = 'Glucose-dependent insulinotropic receptor' and Ligand = 'BDBM50400373'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glucose-dependent insulinotropic receptor


(Homo sapiens (Human))		BDBM50400373
PNG
(CHEMBL2181682)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc2N(CCc12)c1ccc(nc1)S(C)(=O)=O
Show InChI InChI=1S/C21H27N5O5S/c1-14(2)30-21(27)25-9-6-16(7-10-25)31-20-17-8-11-26(19(17)23-13-24-20)15-4-5-18(22-12-15)32(3,28)29/h4-5,12-14,16H,6-11H2,1-3H3
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Article
PubMed
n/an/an/an/a 251n/an/an/an/a



GlaxoSmithKline Research& Development

Curated by ChEMBL


Assay Description
Agonist activity at human GPR119 receptor expressed in CHO-K1 cells co-expressing 6CRE-luciferase gene after 5 hrs by luciferase reporter gene assay

J Med Chem 55: 10972-94 (2012)


Article DOI: 10.1021/jm301404a
BindingDB Entry DOI: 10.7270/Q2RJ4KMK
More data for this
Ligand-Target Pair