Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Glutamate receptor ionotropic, NMDA 2B' and Ligand = 'BDBM50269751'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Glutamate receptor ionotropic, NMDA 2B (Mus musculus)	BDBM50269751 (CHEMBL4065330) Show SMILES O[C@]1(Cc2cc(on2)-c2ccc(=O)[nH]c2)CC[C@H](Cc2ccccc2)CC1 |r,wD:1.0,17.19,(15.39,-6.27,;16.16,-7.61,;14.62,-7.61,;13.85,-8.94,;12.32,-9.1,;12,-10.6,;13.33,-11.37,;14.48,-10.34,;10.59,-11.23,;9.35,-10.32,;7.95,-10.95,;7.79,-12.48,;6.38,-13.11,;9.04,-13.39,;10.44,-12.76,;17.49,-6.83,;18.82,-7.61,;18.82,-9.15,;20.15,-9.92,;21.49,-9.15,;22.82,-9.92,;24.15,-9.16,;24.16,-7.62,;22.81,-6.84,;21.48,-7.62,;17.49,-9.91,;16.16,-9.15,)| Show InChI InChI=1S/C22H24N2O3/c25-21-7-6-18(15-23-21)20-13-19(24-27-20)14-22(26)10-8-17(9-11-22)12-16-4-2-1-3-5-16/h1-7,13,15,17,26H,8-12,14H2,(H,23,25)/t17-,22+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Antagonist activity at mouse NR2B expressed in Hek293 cells co-expressing mouse NR1 assessed as inhibition of glutamic acid/glycine-induced intracell...				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair
Glutamate receptor ionotropic, NMDA 2B (Rattus norvegicus (Rat))	BDBM50269751 (CHEMBL4065330) Show SMILES O[C@]1(Cc2cc(on2)-c2ccc(=O)[nH]c2)CC[C@H](Cc2ccccc2)CC1 |r,wD:1.0,17.19,(15.39,-6.27,;16.16,-7.61,;14.62,-7.61,;13.85,-8.94,;12.32,-9.1,;12,-10.6,;13.33,-11.37,;14.48,-10.34,;10.59,-11.23,;9.35,-10.32,;7.95,-10.95,;7.79,-12.48,;6.38,-13.11,;9.04,-13.39,;10.44,-12.76,;17.49,-6.83,;18.82,-7.61,;18.82,-9.15,;20.15,-9.92,;21.49,-9.15,;22.82,-9.92,;24.15,-9.16,;24.16,-7.62,;22.81,-6.84,;21.48,-7.62,;17.49,-9.91,;16.16,-9.15,)| Show InChI InChI=1S/C22H24N2O3/c25-21-7-6-18(15-23-21)20-13-19(24-27-20)14-22(26)10-8-17(9-11-22)12-16-4-2-1-3-5-16/h1-7,13,15,17,26H,8-12,14H2,(H,23,25)/t17-,22+	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
Medicinal Chemistry Research Laboratory, Shionogi& Co Ltd, 1-1 Futabacho, 3-chome, Toyonaka 561-0825, Japan. Electronic address: kousuke.anan@shionogi.co.jp. Curated by ChEMBL					Assay Description Displacement of [3H]-ifenprodil from NR2B in Wistar rat brain membrane after 120 mins by liquid scintillation counting analysis				Bioorg Med Chem Lett 27: 4194-4198 (2017) Article DOI: 10.1016/j.bmcl.2017.06.076 BindingDB Entry DOI: 10.7270/Q2VX0K0Q
					More data for this Ligand-Target Pair