Found 2 hits Enz. Inhib. hit(s) with Target = 'Gonadotropin-releasing hormone receptor' and Ligand = 'BDBM50121480' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Gonadotropin-releasing hormone receptor
(Homo sapiens (Human)) | BDBM50121480
(5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)Show SMILES Cc1cc2c(cc1Cc1ccc(o1)C(=O)NCC1CCC(CNc3nccc(Cl)n3)CC1)C(C)(C)CCC2(C)C |(-1.64,-16.7,;-3,-15.99,;-4.37,-16.7,;-5.73,-15.99,;-5.73,-14.55,;-4.37,-13.84,;-3,-14.54,;-1.65,-13.82,;-.28,-14.53,;-.28,-15.97,;2.44,-15.99,;2.44,-14.54,;1.08,-13.82,;3.81,-13.82,;3.81,-12.38,;5.17,-14.55,;6.66,-13.66,;8.16,-14.5,;8.2,-16.23,;9.71,-17.04,;11.2,-16.18,;12.71,-17.02,;14.19,-16.13,;15.6,-17.12,;17.17,-16.39,;18.58,-17.37,;18.43,-19.1,;16.88,-19.84,;16.73,-21.55,;15.46,-18.85,;11.17,-14.45,;9.65,-13.61,;-7.08,-13.82,;-8.46,-13.11,;-5.73,-13.1,;-8.43,-14.55,;-8.43,-15.99,;-7.08,-16.7,;-8.46,-17.41,;-5.73,-17.41,)| Show InChI InChI=1S/C33H43ClN4O2/c1-21-16-26-27(33(4,5)14-13-32(26,2)3)18-24(21)17-25-10-11-28(40-25)30(39)36-19-22-6-8-23(9-7-22)20-37-31-35-15-12-29(34)38-31/h10-12,15-16,18,22-23H,6-9,13-14,17,19-20H2,1-5H3,(H,36,39)(H,35,37,38) | PDB
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development-La Jolla/Agouron Pharmaceuticals
Curated by ChEMBL
| Assay Description
In vitro binding affinity towards human gonadotropin-releasing hormone receptor |
Bioorg Med Chem Lett 12: 3635-9 (2002)
BindingDB Entry DOI: 10.7270/Q2XK8DXZ |
More data for this
Ligand-Target Pair | |
Gonadotropin-releasing hormone receptor
(Rattus norvegicus) | BDBM50121480
(5-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphth...)Show SMILES Cc1cc2c(cc1Cc1ccc(o1)C(=O)NCC1CCC(CNc3nccc(Cl)n3)CC1)C(C)(C)CCC2(C)C |(-1.64,-16.7,;-3,-15.99,;-4.37,-16.7,;-5.73,-15.99,;-5.73,-14.55,;-4.37,-13.84,;-3,-14.54,;-1.65,-13.82,;-.28,-14.53,;-.28,-15.97,;2.44,-15.99,;2.44,-14.54,;1.08,-13.82,;3.81,-13.82,;3.81,-12.38,;5.17,-14.55,;6.66,-13.66,;8.16,-14.5,;8.2,-16.23,;9.71,-17.04,;11.2,-16.18,;12.71,-17.02,;14.19,-16.13,;15.6,-17.12,;17.17,-16.39,;18.58,-17.37,;18.43,-19.1,;16.88,-19.84,;16.73,-21.55,;15.46,-18.85,;11.17,-14.45,;9.65,-13.61,;-7.08,-13.82,;-8.46,-13.11,;-5.73,-13.1,;-8.43,-14.55,;-8.43,-15.99,;-7.08,-16.7,;-8.46,-17.41,;-5.73,-17.41,)| Show InChI InChI=1S/C33H43ClN4O2/c1-21-16-26-27(33(4,5)14-13-32(26,2)3)18-24(21)17-25-10-11-28(40-25)30(39)36-19-22-6-8-23(9-7-22)20-37-31-35-15-12-29(34)38-31/h10-12,15-16,18,22-23H,6-9,13-14,17,19-20H2,1-5H3,(H,36,39)(H,35,37,38) | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 5.21E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Global Research and Development-La Jolla/Agouron Pharmaceuticals
Curated by ChEMBL
| Assay Description
In vitro binding affinity towards rat gonadotropin-releasing hormone receptor |
Bioorg Med Chem Lett 12: 3635-9 (2002)
BindingDB Entry DOI: 10.7270/Q2XK8DXZ |
More data for this
Ligand-Target Pair | |
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