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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Growth hormone secretagogue receptor type 1' and Ligand = 'BDBM50422311'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))
BDBM50422311
PNG
(CHEMBL2310890)
Show SMILES C\C=C\C=CC=CC(=O)OC[C@H](NC(=O)[C@H](CO)NC(=O)CN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(O)=O |r,w:5.4,3.2,wU:178.182,223.229,185.190,54.56,45.45,11.11,67.68,104.106,157.159,142.144,86.88,122.124,211.215,15.17,194.198,227.232,wD:97.99,151.153,26.25,58.59,37.37,166.168,77.79,113.115,133.135,203.207,189.194,(48.31,-12.34,;47.17,-11.31,;47.49,-9.8,;46.34,-8.77,;46.66,-7.27,;45.52,-6.24,;45.84,-4.73,;44.69,-3.7,;43.23,-4.18,;45.01,-2.19,;43.87,-1.16,;44.19,.34,;45.65,.82,;45.97,2.33,;44.83,3.36,;47.44,2.8,;48.58,1.77,;48.26,.26,;47.76,4.31,;49.22,4.78,;50.37,3.75,;49.54,6.29,;51.01,6.77,;43.04,1.37,;41.58,.9,;43.36,2.88,;42.22,3.91,;42.54,5.42,;41.4,6.45,;39.93,5.97,;38.79,7,;39.11,8.51,;40.57,8.98,;41.72,7.95,;40.76,3.43,;39.61,4.46,;40.44,1.93,;38.97,1.45,;37.83,2.48,;36.36,2.01,;36.04,.5,;35.22,3.04,;38.65,-.05,;39.8,-1.08,;37.19,-.53,;36.87,-2.04,;38.01,-3.07,;37.69,-4.57,;35.4,-2.51,;34.26,-1.48,;35.08,-4.02,;36.11,-5.16,;35.34,-6.5,;33.84,-6.18,;33.67,-4.65,;32.34,-3.88,;32.34,-2.34,;31.01,-4.65,;29.67,-3.88,;29.67,-2.34,;28.34,-1.57,;28.34,-.03,;29.67,.74,;27.01,.74,;28.34,-4.65,;28.34,-6.19,;27.01,-3.88,;25.67,-4.65,;25.67,-6.19,;24.34,-6.96,;22.93,-6.33,;21.9,-7.47,;22.67,-8.81,;24.18,-8.49,;24.34,-3.88,;24.34,-2.34,;23,-4.65,;21.67,-3.88,;21.67,-2.34,;23,-1.57,;23,-.03,;21.67,.74,;24.34,.74,;20.34,-4.65,;20.34,-6.19,;19,-3.88,;17.67,-4.65,;17.67,-6.19,;16.34,-6.96,;16.34,-8.5,;15,-9.27,;15,-10.81,;13.67,-11.58,;16.34,-11.58,;16.34,-3.88,;16.34,-2.34,;15,-4.65,;13.67,-3.88,;13.67,-2.34,;12.34,-1.57,;15,-1.57,;12.34,-4.65,;12.34,-6.19,;11,-3.88,;9.67,-4.65,;9.67,-6.19,;8.33,-6.96,;8.33,-8.5,;7,-9.27,;9.67,-9.27,;8.33,-3.88,;8.33,-2.34,;7,-4.65,;5.67,-3.88,;5.67,-2.34,;7,-1.57,;7,-.03,;5.67,.74,;8.33,.74,;4.33,-4.65,;4.33,-6.19,;3,-3.88,;1.67,-4.65,;1.67,-6.19,;.33,-6.96,;.33,-8.5,;1.67,-9.27,;1.67,-10.81,;3,-11.58,;.33,-11.58,;.33,-3.88,;.33,-2.34,;-1,-4.65,;-2.34,-3.88,;-2.34,-2.34,;-1,-1.57,;-1,-.03,;.33,.74,;.33,2.28,;-3.67,-4.65,;-3.67,-6.19,;-5,-3.88,;-6.34,-4.65,;-6.34,-6.19,;-7.67,-6.96,;-7.67,-8.5,;-9,-9.27,;-6.34,-9.27,;-7.67,-3.88,;-7.67,-2.34,;-9,-4.65,;-10.34,-3.88,;-10.34,-2.34,;-11.67,-1.57,;-11.67,-4.65,;-11.67,-6.19,;-13,-3.88,;-14.34,-4.65,;-14.34,-6.19,;-15.67,-6.96,;-15.67,-8.5,;-17.01,-9.27,;-17.01,-10.81,;-15.67,-3.88,;-15.67,-2.34,;-17.01,-4.65,;-18.34,-3.88,;-18.34,-2.34,;-17.01,-1.57,;-17.01,-.03,;-15.67,.74,;-15.67,2.28,;-19.67,-4.65,;-21.01,-3.88,;-19.67,-6.19,;-18.43,-7.09,;-18.9,-8.55,;-20.44,-8.55,;-20.92,-7.09,;-22.38,-6.61,;-22.7,-5.11,;-23.53,-7.64,;-23.37,-9.18,;-24.77,-9.8,;-25.8,-8.66,;-25.03,-7.32,;-25.66,-5.92,;-27.19,-5.76,;-24.76,-4.67,;-25.38,-3.26,;-24.48,-2.02,;-26.91,-3.1,;-27.82,-4.35,;-27.54,-1.7,;-29.07,-1.54,;-29.98,-2.78,;-29.35,-4.19,;-30.26,-5.43,;-29.63,-6.84,;-30.53,-8.09,;-29.7,-.13,;-28.79,1.12,;-31.23,.03,;-31.86,1.44,;-30.95,2.68,;-31.58,4.09,;-33.11,4.25,;-30.67,5.34,;-33.39,1.6,;-34.29,.35,;-34.01,3.01,;-35.55,3.17,;-36.45,1.92,;-37.98,2.08,;-38.89,.84,;-40.42,1,;-38.26,-.57,;-36.17,4.57,;-35.27,5.82,;-37.7,4.74,;-38.73,3.59,;-40.14,4.22,;-39.98,5.75,;-38.47,6.07,;-37.85,7.48,;-36.32,7.64,;-38.75,8.72,;-40.28,8.56,;-40.91,7.15,;-42.44,6.99,;-43.07,5.59,;-44.6,5.42,;-45.5,6.67,;-47.04,6.51,;-44.88,8.08,;-41.19,9.81,;-40.56,11.21,;-42.72,9.65,)|
Show InChI InChI=1S/C149H243N47O42/c1-9-10-11-12-16-45-118(209)238-78-106(191-135(225)103(75-197)171-115(204)73-154)137(227)187-101(71-84-32-14-13-15-33-84)133(223)186-100(70-81(4)5)132(222)190-105(77-199)144(234)194-66-29-42-108(194)139(229)180-95(51-57-117(207)208)128(218)188-102(72-85-74-165-79-169-85)134(224)179-92(47-53-112(156)201)126(216)175-90(39-26-63-167-148(161)162)130(220)192-119(82(6)7)141(231)181-93(48-54-113(157)202)127(217)177-91(46-52-111(155)200)125(215)174-89(38-25-62-166-147(159)160)122(212)173-87(35-18-22-59-151)121(211)178-94(50-56-116(205)206)129(219)189-104(76-198)136(226)176-88(36-19-23-60-152)123(213)182-96(37-20-24-61-153)142(232)196-68-31-44-110(196)145(235)195-67-30-41-107(195)138(228)170-83(8)120(210)172-86(34-17-21-58-150)124(214)185-99(69-80(2)3)131(221)183-97(49-55-114(158)203)143(233)193-65-28-43-109(193)140(230)184-98(146(236)237)40-27-64-168-149(163)164/h9-16,32-33,45,74,79-83,86-110,119,197-199H,17-31,34-44,46-73,75-78,150-154H2,1-8H3,(H2,155,200)(H2,156,201)(H2,157,202)(H2,158,203)(H,165,169)(H,170,228)(H,171,204)(H,172,210)(H,173,212)(H,174,215)(H,175,216)(H,176,226)(H,177,217)(H,178,211)(H,179,224)(H,180,229)(H,181,231)(H,182,213)(H,183,221)(H,184,230)(H,185,214)(H,186,223)(H,187,227)(H,188,218)(H,189,219)(H,190,222)(H,191,225)(H,192,220)(H,205,206)(H,207,208)(H,236,237)(H4,159,160,166)(H4,161,162,167)(H4,163,164,168)/b10-9+,12-11?,45-16?/t83-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,119-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

PubMed
n/an/a 0.980n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Binding affinity to cloned human growth hormone secretagogue receptor type 1 in a competitive binding assay with [35S]-MK-0677 as a radiolabeled liga...


J Med Chem 43: 4370-6 (2000)


BindingDB Entry DOI: 10.7270/Q2T72GP0
More data for this
Ligand-Target Pair