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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Growth hormone secretagogue receptor type 1' and Ligand = 'BDBM50539684'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Growth hormone secretagogue receptor type 1


(Homo sapiens (Human))		BDBM50539684
PNG
(CHEMBL4641120)
Show SMILES CCOc1cc(Cl)c(NC(=O)Nc2nc3ccc(CN4CCN(C)CC4)cc3s2)cc1N1CCOCC1
Show InChI InChI=1S/C26H33ClN6O3S/c1-3-36-23-15-19(27)21(16-22(23)33-10-12-35-13-11-33)28-25(34)30-26-29-20-5-4-18(14-24(20)37-26)17-32-8-6-31(2)7-9-32/h4-5,14-16H,3,6-13,17H2,1-2H3,(H2,28,29,30,34)
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n/an/a>5.00E+4n/an/an/an/an/an/a



AstraZeneca

Curated by ChEMBL


Assay Description
Displacement of [125I]-ghrelin from human GHS-R1a stably expressed in HEK cell membrane measured after 60 mins by gamma counter method

Bioorg Med Chem Lett 30: (2020)


Article DOI: 10.1016/j.bmcl.2020.126953
BindingDB Entry DOI: 10.7270/Q2125X5X
More data for this
Ligand-Target Pair