Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Guanylate cyclase soluble subunit alpha-1' and Ligand = 'BDBM323822'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM323822 (US10189809, Compound I-83) Show SMILES COC(=O)Nc1c(N)nc(nc1N)-c1cc(-c2ccccc2)n(Cc2ccccc2F)n1 Show InChI InChI=1S/C22H20FN7O2/c1-32-22(31)26-18-19(24)27-21(28-20(18)25)16-11-17(13-7-3-2-4-8-13)30(29-16)12-14-9-5-6-10-15(14)23/h2-11H,12H2,1H3,(H,26,31)(H4,24,25,27,28)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	2.00E+5	n/a	n/a	n/a	n/a
Ironwood Pharmaceuticals, Inc. US Patent					Assay Description Human embryonic kidney cells (HEK293), endogenously expressing soluble guanylate cyclase (sGC), were used to evaluate the activity of test compounds....				US Patent US10189809 (2019) BindingDB Entry DOI: 10.7270/Q27H1MQ6
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