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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Hepatocyte growth factor activator' and Ligand = 'BDBM50512103'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Hepatocyte growth factor activator


(Homo sapiens (Human))		BDBM50512103
PNG
(CHEMBL4464524)
Show SMILES CC(C)C[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(C)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccc(cc2s1)C(=O)NCc1ccc(cc1)C(O)=O |r|
Show InChI InChI=1S/C42H61N13O8S/c1-23(2)20-32(54-37(60)31(10-7-19-49-42(46)47)53-36(59)30(51-24(3)56)8-4-5-17-43)38(61)52-29(9-6-18-48-41(44)45)34(57)39-55-28-16-15-27(21-33(28)64-39)35(58)50-22-25-11-13-26(14-12-25)40(62)63/h11-16,21,23,29-32H,4-10,17-20,22,43H2,1-3H3,(H,50,58)(H,51,56)(H,52,61)(H,53,59)(H,54,60)(H,62,63)(H4,44,45,48)(H4,46,47,49)/t29-,30-,31-,32-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
 3.70n/an/an/an/an/an/an/an/a



Universidade Federal de Pernambuco

Curated by ChEMBL


Assay Description
Inhibition of recombinant HGFA serine protease domain (unknown origin) preincubated for 30 mins followed by Boc-QLR-AMC substrate addition by fluores...

Eur J Med Chem 170: 237-260 (2019)


Article DOI: 10.1016/j.ejmech.2019.03.024
BindingDB Entry DOI: 10.7270/Q2X92FNR
More data for this
Ligand-Target Pair