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Found 1 hit Enz. Inhib. hit(s) with Target = 'Hepatocyte growth factor receptor' and Ligand = 'BDBM50035421'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM50035421
PNG
(CHEMBL3343394)
Show SMILES COc1cc2c(Oc3ccc(NC(=O)c4nnn(c4C(F)(F)F)-c4cccc(Br)c4)cc3F)ccnc2cc1OCCCN1CCC(C)CC1
Show InChI InChI=1S/C35H33BrF4N6O4/c1-21-10-14-45(15-11-21)13-4-16-49-31-20-27-25(19-30(31)48-2)28(9-12-41-27)50-29-8-7-23(18-26(29)37)42-34(47)32-33(35(38,39)40)46(44-43-32)24-6-3-5-22(36)17-24/h3,5-9,12,17-21H,4,10-11,13-16H2,1-2H3,(H,42,47)
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Article
PubMed
n/an/a 5.30n/an/an/an/an/an/a



Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University)

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) using poly (Glu, Tyr) 4:1 substrate incubated for 30 mins by HTRF assay

Bioorg Med Chem 22: 6438-52 (2014)


Article DOI: 10.1016/j.bmc.2014.09.037
BindingDB Entry DOI: 10.7270/Q2BG2QM2
More data for this
Ligand-Target Pair