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Found 18 hits Enz. Inhib. hit(s) with Target = 'Hepatocyte growth factor receptor' and Ligand = 'BDBM50146166'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50146166
PNG
(CHEMBL3765306)
Show SMILES Cl.CC1=[N+](C(=O)C(C=C1)C(=O)Nc1ccc(Oc2ccc3nc(NC(=O)C4CC4)cn3c2)c(F)c1)c1ccccc1 |c:6,t:1|
Show InChI InChI=1S/C30H24FN5O4.ClH/c1-18-7-12-23(30(39)36(18)21-5-3-2-4-6-21)29(38)32-20-10-13-25(24(31)15-20)40-22-11-14-27-33-26(17-35(27)16-22)34-28(37)19-8-9-19;/h2-7,10-17,19,23H,8-9H2,1H3,(H-,32,34,37,38);1H/p+1
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n/an/a>1.80n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of constitutively activated c-Met phosphorylation in human Hs 746T cells assessed as cell viability after 72 hrs by CCK8 assay


Eur J Med Chem 108: 495-504 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.016
BindingDB Entry DOI: 10.7270/Q2G73GMC
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50146166
PNG
(CHEMBL3765306)
Show SMILES Cl.CC1=[N+](C(=O)C(C=C1)C(=O)Nc1ccc(Oc2ccc3nc(NC(=O)C4CC4)cn3c2)c(F)c1)c1ccccc1 |c:6,t:1|
Show InChI InChI=1S/C30H24FN5O4.ClH/c1-18-7-12-23(30(39)36(18)21-5-3-2-4-6-21)29(38)32-20-10-13-25(24(31)15-20)40-22-11-14-27-33-26(17-35(27)16-22)34-28(37)19-8-9-19;/h2-7,10-17,19,23H,8-9H2,1H3,(H-,32,34,37,38);1H/p+1
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n/an/a>1.80n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of constitutively activated c-Met phosphorylation in human A549 cells assessed as cell viability after 72 hrs by CCK8 assay


Eur J Med Chem 108: 495-504 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.016
BindingDB Entry DOI: 10.7270/Q2G73GMC
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50146166
PNG
(CHEMBL3765306)
Show SMILES Cl.CC1=[N+](C(=O)C(C=C1)C(=O)Nc1ccc(Oc2ccc3nc(NC(=O)C4CC4)cn3c2)c(F)c1)c1ccccc1 |c:6,t:1|
Show InChI InChI=1S/C30H24FN5O4.ClH/c1-18-7-12-23(30(39)36(18)21-5-3-2-4-6-21)29(38)32-20-10-13-25(24(31)15-20)40-22-11-14-27-33-26(17-35(27)16-22)34-28(37)19-8-9-19;/h2-7,10-17,19,23H,8-9H2,1H3,(H-,32,34,37,38);1H/p+1
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n/an/a>1.80n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of constitutively activated c-Met phosphorylation in human SNU5 cells assessed as cell viability after 72 hrs by CCK8 assay


Eur J Med Chem 108: 495-504 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.016
BindingDB Entry DOI: 10.7270/Q2G73GMC
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50146166
PNG
(CHEMBL3765306)
Show SMILES Cl.CC1=[N+](C(=O)C(C=C1)C(=O)Nc1ccc(Oc2ccc3nc(NC(=O)C4CC4)cn3c2)c(F)c1)c1ccccc1 |c:6,t:1|
Show InChI InChI=1S/C30H24FN5O4.ClH/c1-18-7-12-23(30(39)36(18)21-5-3-2-4-6-21)29(38)32-20-10-13-25(24(31)15-20)40-22-11-14-27-33-26(17-35(27)16-22)34-28(37)19-8-9-19;/h2-7,10-17,19,23H,8-9H2,1H3,(H-,32,34,37,38);1H/p+1
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n/an/a>1.80n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of constitutively activated c-Met phosphorylation in HUVEC assessed as cell viability after 72 hrs by CCK8 assay


Eur J Med Chem 108: 495-504 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.016
BindingDB Entry DOI: 10.7270/Q2G73GMC
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50146166
PNG
(CHEMBL3765306)
Show SMILES Cl.CC1=[N+](C(=O)C(C=C1)C(=O)Nc1ccc(Oc2ccc3nc(NC(=O)C4CC4)cn3c2)c(F)c1)c1ccccc1 |c:6,t:1|
Show InChI InChI=1S/C30H24FN5O4.ClH/c1-18-7-12-23(30(39)36(18)21-5-3-2-4-6-21)29(38)32-20-10-13-25(24(31)15-20)40-22-11-14-27-33-26(17-35(27)16-22)34-28(37)19-8-9-19;/h2-7,10-17,19,23H,8-9H2,1H3,(H-,32,34,37,38);1H/p+1
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n/an/a>1.80n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of constitutively activated c-Met phosphorylation in human SNU638 cells assessed as cell viability after 72 hrs by CCK8 assay


Eur J Med Chem 108: 495-504 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.016
BindingDB Entry DOI: 10.7270/Q2G73GMC
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50146166
PNG
(CHEMBL3765306)
Show SMILES Cl.CC1=[N+](C(=O)C(C=C1)C(=O)Nc1ccc(Oc2ccc3nc(NC(=O)C4CC4)cn3c2)c(F)c1)c1ccccc1 |c:6,t:1|
Show InChI InChI=1S/C30H24FN5O4.ClH/c1-18-7-12-23(30(39)36(18)21-5-3-2-4-6-21)29(38)32-20-10-13-25(24(31)15-20)40-22-11-14-27-33-26(17-35(27)16-22)34-28(37)19-8-9-19;/h2-7,10-17,19,23H,8-9H2,1H3,(H-,32,34,37,38);1H/p+1
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n/an/a>1.80n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of constitutively activated c-Met phosphorylation in human MKN45 cells assessed as cell viability after 72 hrs by CCK8 assay


Eur J Med Chem 108: 495-504 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.016
BindingDB Entry DOI: 10.7270/Q2G73GMC
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50146166
PNG
(CHEMBL3765306)
Show SMILES Cl.CC1=[N+](C(=O)C(C=C1)C(=O)Nc1ccc(Oc2ccc3nc(NC(=O)C4CC4)cn3c2)c(F)c1)c1ccccc1 |c:6,t:1|
Show InChI InChI=1S/C30H24FN5O4.ClH/c1-18-7-12-23(30(39)36(18)21-5-3-2-4-6-21)29(38)32-20-10-13-25(24(31)15-20)40-22-11-14-27-33-26(17-35(27)16-22)34-28(37)19-8-9-19;/h2-7,10-17,19,23H,8-9H2,1H3,(H-,32,34,37,38);1H/p+1
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n/an/a>1.80n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of constitutively activated c-Met phosphorylation in human EBC1 cells assessed as cell viability after 72 hrs by CCK8 assay


Eur J Med Chem 108: 495-504 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.016
BindingDB Entry DOI: 10.7270/Q2G73GMC
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50146166
PNG
(CHEMBL3765306)
Show SMILES Cl.CC1=[N+](C(=O)C(C=C1)C(=O)Nc1ccc(Oc2ccc3nc(NC(=O)C4CC4)cn3c2)c(F)c1)c1ccccc1 |c:6,t:1|
Show InChI InChI=1S/C30H24FN5O4.ClH/c1-18-7-12-23(30(39)36(18)21-5-3-2-4-6-21)29(38)32-20-10-13-25(24(31)15-20)40-22-11-14-27-33-26(17-35(27)16-22)34-28(37)19-8-9-19;/h2-7,10-17,19,23H,8-9H2,1H3,(H-,32,34,37,38);1H/p+1
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n/an/a>1.80n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of constitutively activated c-Met phosphorylation in human NUGC4 cells assessed as cell viability after 72 hrs by CCK8 assay


Eur J Med Chem 108: 495-504 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.016
BindingDB Entry DOI: 10.7270/Q2G73GMC
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50146166
PNG
(CHEMBL3765306)
Show SMILES Cl.CC1=[N+](C(=O)C(C=C1)C(=O)Nc1ccc(Oc2ccc3nc(NC(=O)C4CC4)cn3c2)c(F)c1)c1ccccc1 |c:6,t:1|
Show InChI InChI=1S/C30H24FN5O4.ClH/c1-18-7-12-23(30(39)36(18)21-5-3-2-4-6-21)29(38)32-20-10-13-25(24(31)15-20)40-22-11-14-27-33-26(17-35(27)16-22)34-28(37)19-8-9-19;/h2-7,10-17,19,23H,8-9H2,1H3,(H-,32,34,37,38);1H/p+1
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n/an/a>1.80n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of constitutively activated c-Met phosphorylation in human COLO205 cells assessed as cell viability after 72 hrs by CCK8 assay


Eur J Med Chem 108: 495-504 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.016
BindingDB Entry DOI: 10.7270/Q2G73GMC
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50146166
PNG
(CHEMBL3765306)
Show SMILES Cl.CC1=[N+](C(=O)C(C=C1)C(=O)Nc1ccc(Oc2ccc3nc(NC(=O)C4CC4)cn3c2)c(F)c1)c1ccccc1 |c:6,t:1|
Show InChI InChI=1S/C30H24FN5O4.ClH/c1-18-7-12-23(30(39)36(18)21-5-3-2-4-6-21)29(38)32-20-10-13-25(24(31)15-20)40-22-11-14-27-33-26(17-35(27)16-22)34-28(37)19-8-9-19;/h2-7,10-17,19,23H,8-9H2,1H3,(H-,32,34,37,38);1H/p+1
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n/an/a>1.80n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of constitutively activated c-Met phosphorylation in human OE33 cells assessed as cell viability after 72 hrs by CCK8 assay


Eur J Med Chem 108: 495-504 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.016
BindingDB Entry DOI: 10.7270/Q2G73GMC
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50146166
PNG
(CHEMBL3765306)
Show SMILES Cl.CC1=[N+](C(=O)C(C=C1)C(=O)Nc1ccc(Oc2ccc3nc(NC(=O)C4CC4)cn3c2)c(F)c1)c1ccccc1 |c:6,t:1|
Show InChI InChI=1S/C30H24FN5O4.ClH/c1-18-7-12-23(30(39)36(18)21-5-3-2-4-6-21)29(38)32-20-10-13-25(24(31)15-20)40-22-11-14-27-33-26(17-35(27)16-22)34-28(37)19-8-9-19;/h2-7,10-17,19,23H,8-9H2,1H3,(H-,32,34,37,38);1H/p+1
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n/an/a>1.80n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of constitutively activated c-Met phosphorylation in human KATO III cells assessed as cell viability after 72 hrs by CCK8 assay


Eur J Med Chem 108: 495-504 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.016
BindingDB Entry DOI: 10.7270/Q2G73GMC
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50146166
PNG
(CHEMBL3765306)
Show SMILES Cl.CC1=[N+](C(=O)C(C=C1)C(=O)Nc1ccc(Oc2ccc3nc(NC(=O)C4CC4)cn3c2)c(F)c1)c1ccccc1 |c:6,t:1|
Show InChI InChI=1S/C30H24FN5O4.ClH/c1-18-7-12-23(30(39)36(18)21-5-3-2-4-6-21)29(38)32-20-10-13-25(24(31)15-20)40-22-11-14-27-33-26(17-35(27)16-22)34-28(37)19-8-9-19;/h2-7,10-17,19,23H,8-9H2,1H3,(H-,32,34,37,38);1H/p+1
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n/an/a>1.80n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of constitutively activated c-Met phosphorylation in human SNU620 cells assessed as cell viability after 72 hrs by CCK8 assay


Eur J Med Chem 108: 495-504 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.016
BindingDB Entry DOI: 10.7270/Q2G73GMC
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50146166
PNG
(CHEMBL3765306)
Show SMILES Cl.CC1=[N+](C(=O)C(C=C1)C(=O)Nc1ccc(Oc2ccc3nc(NC(=O)C4CC4)cn3c2)c(F)c1)c1ccccc1 |c:6,t:1|
Show InChI InChI=1S/C30H24FN5O4.ClH/c1-18-7-12-23(30(39)36(18)21-5-3-2-4-6-21)29(38)32-20-10-13-25(24(31)15-20)40-22-11-14-27-33-26(17-35(27)16-22)34-28(37)19-8-9-19;/h2-7,10-17,19,23H,8-9H2,1H3,(H-,32,34,37,38);1H/p+1
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n/an/a>1.80n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of constitutively activated c-Met phosphorylation in human SNU668 cells assessed as cell viability after 72 hrs by CCK8 assay


Eur J Med Chem 108: 495-504 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.016
BindingDB Entry DOI: 10.7270/Q2G73GMC
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50146166
PNG
(CHEMBL3765306)
Show SMILES Cl.CC1=[N+](C(=O)C(C=C1)C(=O)Nc1ccc(Oc2ccc3nc(NC(=O)C4CC4)cn3c2)c(F)c1)c1ccccc1 |c:6,t:1|
Show InChI InChI=1S/C30H24FN5O4.ClH/c1-18-7-12-23(30(39)36(18)21-5-3-2-4-6-21)29(38)32-20-10-13-25(24(31)15-20)40-22-11-14-27-33-26(17-35(27)16-22)34-28(37)19-8-9-19;/h2-7,10-17,19,23H,8-9H2,1H3,(H-,32,34,37,38);1H/p+1
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n/an/a>1.80n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of constitutively activated c-Met phosphorylation in human U87MG cells assessed as cell viability after 72 hrs by CCK8 assay


Eur J Med Chem 108: 495-504 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.016
BindingDB Entry DOI: 10.7270/Q2G73GMC
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50146166
PNG
(CHEMBL3765306)
Show SMILES Cl.CC1=[N+](C(=O)C(C=C1)C(=O)Nc1ccc(Oc2ccc3nc(NC(=O)C4CC4)cn3c2)c(F)c1)c1ccccc1 |c:6,t:1|
Show InChI InChI=1S/C30H24FN5O4.ClH/c1-18-7-12-23(30(39)36(18)21-5-3-2-4-6-21)29(38)32-20-10-13-25(24(31)15-20)40-22-11-14-27-33-26(17-35(27)16-22)34-28(37)19-8-9-19;/h2-7,10-17,19,23H,8-9H2,1H3,(H-,32,34,37,38);1H/p+1
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n/an/a>1.80n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of constitutively activated c-Met phosphorylation in human SNU484 cells assessed as cell viability after 72 hrs by CCK8 assay


Eur J Med Chem 108: 495-504 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.016
BindingDB Entry DOI: 10.7270/Q2G73GMC
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50146166
PNG
(CHEMBL3765306)
Show SMILES Cl.CC1=[N+](C(=O)C(C=C1)C(=O)Nc1ccc(Oc2ccc3nc(NC(=O)C4CC4)cn3c2)c(F)c1)c1ccccc1 |c:6,t:1|
Show InChI InChI=1S/C30H24FN5O4.ClH/c1-18-7-12-23(30(39)36(18)21-5-3-2-4-6-21)29(38)32-20-10-13-25(24(31)15-20)40-22-11-14-27-33-26(17-35(27)16-22)34-28(37)19-8-9-19;/h2-7,10-17,19,23H,8-9H2,1H3,(H-,32,34,37,38);1H/p+1
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n/an/a>1.80n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of constitutively activated c-Met phosphorylation in human AGS cells assessed as cell viability after 72 hrs by CCK8 assay


Eur J Med Chem 108: 495-504 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.016
BindingDB Entry DOI: 10.7270/Q2G73GMC
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50146166
PNG
(CHEMBL3765306)
Show SMILES Cl.CC1=[N+](C(=O)C(C=C1)C(=O)Nc1ccc(Oc2ccc3nc(NC(=O)C4CC4)cn3c2)c(F)c1)c1ccccc1 |c:6,t:1|
Show InChI InChI=1S/C30H24FN5O4.ClH/c1-18-7-12-23(30(39)36(18)21-5-3-2-4-6-21)29(38)32-20-10-13-25(24(31)15-20)40-22-11-14-27-33-26(17-35(27)16-22)34-28(37)19-8-9-19;/h2-7,10-17,19,23H,8-9H2,1H3,(H-,32,34,37,38);1H/p+1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 1.90n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) by AlphaScreen assay


Eur J Med Chem 108: 495-504 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.016
BindingDB Entry DOI: 10.7270/Q2G73GMC
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50146166
PNG
(CHEMBL3765306)
Show SMILES Cl.CC1=[N+](C(=O)C(C=C1)C(=O)Nc1ccc(Oc2ccc3nc(NC(=O)C4CC4)cn3c2)c(F)c1)c1ccccc1 |c:6,t:1|
Show InChI InChI=1S/C30H24FN5O4.ClH/c1-18-7-12-23(30(39)36(18)21-5-3-2-4-6-21)29(38)32-20-10-13-25(24(31)15-20)40-22-11-14-27-33-26(17-35(27)16-22)34-28(37)19-8-9-19;/h2-7,10-17,19,23H,8-9H2,1H3,(H-,32,34,37,38);1H/p+1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars

Article
PubMed
n/an/a 8.80n/an/an/an/an/an/a



Shenyang Pharmaceutical University

Curated by ChEMBL


Assay Description
Inhibition of HGF induced c-Met phosphorylation in human A549 cells after 10 mins by Western blot analysis


Eur J Med Chem 108: 495-504 (2016)


Article DOI: 10.1016/j.ejmech.2015.12.016
BindingDB Entry DOI: 10.7270/Q2G73GMC
More data for this
Ligand-Target Pair