BindingDB PrimarySearch

Found 8 hits Enz. Inhib. hit(s) with Target = 'Hepatocyte growth factor receptor' and Ligand = 'BDBM50299777'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50299777 (CHEMBL573761 \| N-(4-(6,7-dimethoxyquinolin-4-yloxy...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	1.70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of recombinant c-met-mediated gastrin phosphorylation by HTRF assay				J Med Chem 55: 1858-67 (2012) Article DOI: 10.1021/jm201330u BindingDB Entry DOI: 10.7270/Q2ZK5HQP
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50299777 (CHEMBL573761 \| N-(4-(6,7-dimethoxyquinolin-4-yloxy...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars		n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
MethylGene Inc.					Assay Description Inhibition assay using kinase inhibitors.				International Journal of Medicinal Chemistry 2012: 1-6 (2012) BindingDB Entry DOI: 10.7270/Q2X065P9
MethylGene Inc.					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50299777 (CHEMBL573761 \| N-(4-(6,7-dimethoxyquinolin-4-yloxy...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
MethylGene Inc Curated by ChEMBL					Assay Description Inhibition of GST-tagged c-Met expressed in Sf9 cells				Bioorg Med Chem Lett 19: 6552-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.040 BindingDB Entry DOI: 10.7270/Q2VM4D6R
MethylGene Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50299777 (CHEMBL573761 \| N-(4-(6,7-dimethoxyquinolin-4-yloxy...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars		n/a	n/a	30	n/a	n/a	n/a	n/a	n/a	n/a
MethylGene Inc.					Assay Description Inhibition assay using kinase inhibitors.				International Journal of Medicinal Chemistry 2012: 1-6 (2012) BindingDB Entry DOI: 10.7270/Q2X065P9
MethylGene Inc.					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50299777 (CHEMBL573761 \| N-(4-(6,7-dimethoxyquinolin-4-yloxy...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of HGF-mediated c-met autophosphorylation in serum-starved human PC3 cells after 1 hr by electrochemiluminescent immunoassay				J Med Chem 55: 1858-67 (2012) Article DOI: 10.1021/jm201330u BindingDB Entry DOI: 10.7270/Q2ZK5HQP
Amgen Inc. Curated by ChEMBL					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50299777 (CHEMBL573761 \| N-(4-(6,7-dimethoxyquinolin-4-yloxy...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
MethylGene Inc Curated by ChEMBL					Assay Description Inhibition of c-Met in human DU145 cells assessed as cell scattering				Bioorg Med Chem Lett 19: 6552-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.040 BindingDB Entry DOI: 10.7270/Q2VM4D6R
MethylGene Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50299777 (CHEMBL573761 \| N-(4-(6,7-dimethoxyquinolin-4-yloxy...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	n/a	n/a
MethylGene Inc Curated by ChEMBL					Assay Description Inhibition of c-Met in human A549 cells by wound healing assay				Bioorg Med Chem Lett 19: 6552-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.040 BindingDB Entry DOI: 10.7270/Q2VM4D6R
MethylGene Inc Curated by ChEMBL					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM50299777 (CHEMBL573761 \| N-(4-(6,7-dimethoxyquinolin-4-yloxy...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	90	n/a	n/a	n/a	n/a	n/a	n/a
MethylGene Inc Curated by ChEMBL					Assay Description Inhibition of TPR-Met assessed as autophosphorylation				Bioorg Med Chem Lett 19: 6552-6 (2009) Article DOI: 10.1016/j.bmcl.2009.10.040 BindingDB Entry DOI: 10.7270/Q2VM4D6R
MethylGene Inc Curated by ChEMBL					More data for this Ligand-Target Pair