Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B' and Ligand = 'BDBM50344031'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B (Homo sapiens (Human))	BDBM50344031 (CHEMBL1779986 | trans-(3R,5R)-5-butyl-1-((5-methyl...) Show SMILES CCCC[C@@H]1C[C@H](CN(Cc2nc(oc2C)-c2ccccc2)C1)C(=O)NCc1cccc(C)n1 |r| Show InChI InChI=1S/C28H36N4O2/c1-4-5-11-22-15-24(27(33)29-16-25-14-9-10-20(2)30-25)18-32(17-22)19-26-21(3)34-28(31-26)23-12-7-6-8-13-23/h6-10,12-14,22,24H,4-5,11,15-19H2,1-3H3,(H,29,33)/t22-,24-/m1/s1	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of PDE8B				Bioorg Med Chem Lett 21: 3095-8 (2011) Article DOI: 10.1016/j.bmcl.2011.03.022 BindingDB Entry DOI: 10.7270/Q20002F8
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