Compile Data Set for Download or QSAR

Found 5 hits Enz. Inhib. hit(s) with Target = 'High affinity nerve growth factor receptor' and Ligand = 'BDBM127631'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM127631 (US10251889, Example 4 | US10758542, Example 4 | US...) Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)NCCN3CCOCC3)c2n1 |r| Show InChI InChI=1S/C23H26F2N6O2/c24-16-3-4-19(25)17(14-16)20-2-1-7-30(20)21-5-8-31-22(28-21)18(15-27-31)23(32)26-6-9-29-10-12-33-13-11-29/h3-5,8,14-15,20H,1-2,6-7,9-13H2,(H,26,32)/t20-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.950	n/a	n/a	n/a	n/a	7.5	n/a
Array Biopharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US8791123 (2014) BindingDB Entry DOI: 10.7270/Q2Q23XX7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM127631 (US10251889, Example 4 | US10758542, Example 4 | US...) Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)NCCN3CCOCC3)c2n1 |r| Show InChI InChI=1S/C23H26F2N6O2/c24-16-3-4-19(25)17(14-16)20-2-1-7-30(20)21-5-8-31-22(28-21)18(15-27-31)23(32)26-6-9-29-10-12-33-13-11-29/h3-5,8,14-15,20H,1-2,6-7,9-13H2,(H,26,32)/t20-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.950	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US9782415 (2017) BindingDB Entry DOI: 10.7270/Q2P84F0G
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM127631 (US10251889, Example 4 | US10758542, Example 4 | US...) Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)NCCN3CCOCC3)c2n1 |r| Show InChI InChI=1S/C23H26F2N6O2/c24-16-3-4-19(25)17(14-16)20-2-1-7-30(20)21-5-8-31-22(28-21)18(15-27-31)23(32)26-6-9-29-10-12-33-13-11-29/h3-5,8,14-15,20H,1-2,6-7,9-13H2,(H,26,32)/t20-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.950	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US10758542 (2020) BindingDB Entry DOI: 10.7270/Q2RB77PD
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM127631 (US10251889, Example 4 | US10758542, Example 4 | US...) Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)NCCN3CCOCC3)c2n1 |r| Show InChI InChI=1S/C23H26F2N6O2/c24-16-3-4-19(25)17(14-16)20-2-1-7-30(20)21-5-8-31-22(28-21)18(15-27-31)23(32)26-6-9-29-10-12-33-13-11-29/h3-5,8,14-15,20H,1-2,6-7,9-13H2,(H,26,32)/t20-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.950	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description Trk enzymatic selectivity was assessed using Omnia™ Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) an...				US Patent US9796724 (2017) BindingDB Entry DOI: 10.7270/Q27M0B21
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM127631 (US10251889, Example 4 | US10758542, Example 4 | US...) Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)NCCN3CCOCC3)c2n1 |r| Show InChI InChI=1S/C23H26F2N6O2/c24-16-3-4-19(25)17(14-16)20-2-1-7-30(20)21-5-8-31-22(28-21)18(15-27-31)23(32)26-6-9-29-10-12-33-13-11-29/h3-5,8,14-15,20H,1-2,6-7,9-13H2,(H,26,32)/t20-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2R49T22
					More data for this Ligand-Target Pair