Compile Data Set for Download or QSAR

Found 5 hits Enz. Inhib. hit(s) with Target = 'High affinity nerve growth factor receptor' and Ligand = 'BDBM127636'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM127636 (US10251889, Example 9 | US10758542, Example 9 | US...) Show SMILES CC(C)(CN1CCOCC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C25H30F2N6O2/c1-25(2,16-31-10-12-35-13-11-31)30-24(34)19-15-28-33-9-7-22(29-23(19)33)32-8-3-4-21(32)18-14-17(26)5-6-20(18)27/h5-7,9,14-15,21H,3-4,8,10-13,16H2,1-2H3,(H,30,34)/t21-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.45	n/a	n/a	n/a	n/a	7.5	n/a
Array Biopharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US8791123 (2014) BindingDB Entry DOI: 10.7270/Q2Q23XX7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM127636 (US10251889, Example 9 | US10758542, Example 9 | US...) Show SMILES CC(C)(CN1CCOCC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C25H30F2N6O2/c1-25(2,16-31-10-12-35-13-11-31)30-24(34)19-15-28-33-9-7-22(29-23(19)33)32-8-3-4-21(32)18-14-17(26)5-6-20(18)27/h5-7,9,14-15,21H,3-4,8,10-13,16H2,1-2H3,(H,30,34)/t21-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.45	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US9782415 (2017) BindingDB Entry DOI: 10.7270/Q2P84F0G
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM127636 (US10251889, Example 9 | US10758542, Example 9 | US...) Show SMILES CC(C)(CN1CCOCC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C25H30F2N6O2/c1-25(2,16-31-10-12-35-13-11-31)30-24(34)19-15-28-33-9-7-22(29-23(19)33)32-8-3-4-21(32)18-14-17(26)5-6-20(18)27/h5-7,9,14-15,21H,3-4,8,10-13,16H2,1-2H3,(H,30,34)/t21-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.45	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US10758542 (2020) BindingDB Entry DOI: 10.7270/Q2RB77PD
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM127636 (US10251889, Example 9 | US10758542, Example 9 | US...) Show SMILES CC(C)(CN1CCOCC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C25H30F2N6O2/c1-25(2,16-31-10-12-35-13-11-31)30-24(34)19-15-28-33-9-7-22(29-23(19)33)32-8-3-4-21(32)18-14-17(26)5-6-20(18)27/h5-7,9,14-15,21H,3-4,8,10-13,16H2,1-2H3,(H,30,34)/t21-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.45	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description Trk enzymatic selectivity was assessed using Omnia™ Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) an...				US Patent US9796724 (2017) BindingDB Entry DOI: 10.7270/Q27M0B21
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM127636 (US10251889, Example 9 | US10758542, Example 9 | US...) Show SMILES CC(C)(CN1CCOCC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C25H30F2N6O2/c1-25(2,16-31-10-12-35-13-11-31)30-24(34)19-15-28-33-9-7-22(29-23(19)33)32-8-3-4-21(32)18-14-17(26)5-6-20(18)27/h5-7,9,14-15,21H,3-4,8,10-13,16H2,1-2H3,(H,30,34)/t21-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2R49T22
					More data for this Ligand-Target Pair