Compile Data Set for Download or QSAR

Found 5 hits Enz. Inhib. hit(s) with Target = 'High affinity nerve growth factor receptor' and Ligand = 'BDBM127642'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM127642 (US10251889, Example 15 | US10758542, Example 15 | ...) Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)N[C@H]3CC4CCC3C4)c2n1 |r,THB:22:23:26.27:29| Show InChI InChI=1S/C24H25F2N5O/c25-16-5-6-19(26)17(12-16)21-2-1-8-30(21)22-7-9-31-23(29-22)18(13-27-31)24(32)28-20-11-14-3-4-15(20)10-14/h5-7,9,12-15,20-21H,1-4,8,10-11H2,(H,28,32)/t14?,15?,20-,21+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	7.5	n/a
Array Biopharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US8791123 (2014) BindingDB Entry DOI: 10.7270/Q2Q23XX7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM127642 (US10251889, Example 15 | US10758542, Example 15 | ...) Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)N[C@H]3CC4CCC3C4)c2n1 |r,THB:22:23:26.27:29| Show InChI InChI=1S/C24H25F2N5O/c25-16-5-6-19(26)17(12-16)21-2-1-8-30(21)22-7-9-31-23(29-22)18(13-27-31)24(32)28-20-11-14-3-4-15(20)10-14/h5-7,9,12-15,20-21H,1-4,8,10-11H2,(H,28,32)/t14?,15?,20-,21+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US9782415 (2017) BindingDB Entry DOI: 10.7270/Q2P84F0G
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM127642 (US10251889, Example 15 | US10758542, Example 15 | ...) Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)N[C@H]3CC4CCC3C4)c2n1 |r,THB:22:23:26.27:29| Show InChI InChI=1S/C24H25F2N5O/c25-16-5-6-19(26)17(12-16)21-2-1-8-30(21)22-7-9-31-23(29-22)18(13-27-31)24(32)28-20-11-14-3-4-15(20)10-14/h5-7,9,12-15,20-21H,1-4,8,10-11H2,(H,28,32)/t14?,15?,20-,21+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US10758542 (2020) BindingDB Entry DOI: 10.7270/Q2RB77PD
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM127642 (US10251889, Example 15 | US10758542, Example 15 | ...) Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)N[C@H]3CC4CCC3C4)c2n1 |r,THB:22:23:26.27:29| Show InChI InChI=1S/C24H25F2N5O/c25-16-5-6-19(26)17(12-16)21-2-1-8-30(21)22-7-9-31-23(29-22)18(13-27-31)24(32)28-20-11-14-3-4-15(20)10-14/h5-7,9,12-15,20-21H,1-4,8,10-11H2,(H,28,32)/t14?,15?,20-,21+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description Trk enzymatic selectivity was assessed using Omnia™ Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) an...				US Patent US9796724 (2017) BindingDB Entry DOI: 10.7270/Q27M0B21
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM127642 (US10251889, Example 15 | US10758542, Example 15 | ...) Show SMILES Fc1ccc(F)c(c1)[C@H]1CCCN1c1ccn2ncc(C(=O)N[C@H]3CC4CCC3C4)c2n1 |r,THB:22:23:26.27:29| Show InChI InChI=1S/C24H25F2N5O/c25-16-5-6-19(26)17(12-16)21-2-1-8-30(21)22-7-9-31-23(29-22)18(13-27-31)24(32)28-20-11-14-3-4-15(20)10-14/h5-7,9,12-15,20-21H,1-4,8,10-11H2,(H,28,32)/t14?,15?,20-,21+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	156	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2R49T22
					More data for this Ligand-Target Pair