Found 5 hits Enz. Inhib. hit(s) with Target = 'High affinity nerve growth factor receptor' and Ligand = 'BDBM127662' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM127662
(US10251889, Example 35 | US10758542, Example 35 | ...)Show SMILES O[C@H]1CC[C@@H](CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cccc(F)c1 |r,wU:4.7,wD:23.27,1.0,(6,-6.59,;5.6,-5.1,;6.69,-4.01,;6.29,-2.52,;4.81,-2.12,;3.72,-3.21,;4.12,-4.7,;4.41,-.64,;2.92,-.24,;1.83,-1.33,;2.52,1.25,;3.43,2.5,;2.52,3.74,;1.06,3.27,;-.28,4.04,;-1.61,3.27,;-1.61,1.73,;-.28,.96,;1.06,1.73,;-2.94,.96,;-2.94,-.58,;-4.41,-1.06,;-5.31,.19,;-4.41,1.43,;-4.81,2.92,;-6.29,3.32,;-6.69,4.81,;-5.6,5.9,;-4.12,5.5,;-3.03,6.59,;-3.72,4.01,)| Show InChI InChI=1S/C23H26FN5O2/c24-16-4-1-3-15(13-16)20-5-2-11-28(20)21-10-12-29-22(27-21)19(14-25-29)23(31)26-17-6-8-18(30)9-7-17/h1,3-4,10,12-14,17-18,20,30H,2,5-9,11H2,(H,26,31)/t17-,18-,20-/m1/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Array Biopharma, Inc.
US Patent
| Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ... |
US Patent US8791123 (2014)
BindingDB Entry DOI: 10.7270/Q2Q23XX7 |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM127662
(US10251889, Example 35 | US10758542, Example 35 | ...)Show SMILES O[C@H]1CC[C@@H](CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cccc(F)c1 |r,wU:4.7,wD:23.27,1.0,(6,-6.59,;5.6,-5.1,;6.69,-4.01,;6.29,-2.52,;4.81,-2.12,;3.72,-3.21,;4.12,-4.7,;4.41,-.64,;2.92,-.24,;1.83,-1.33,;2.52,1.25,;3.43,2.5,;2.52,3.74,;1.06,3.27,;-.28,4.04,;-1.61,3.27,;-1.61,1.73,;-.28,.96,;1.06,1.73,;-2.94,.96,;-2.94,-.58,;-4.41,-1.06,;-5.31,.19,;-4.41,1.43,;-4.81,2.92,;-6.29,3.32,;-6.69,4.81,;-5.6,5.9,;-4.12,5.5,;-3.03,6.59,;-3.72,4.01,)| Show InChI InChI=1S/C23H26FN5O2/c24-16-4-1-3-15(13-16)20-5-2-11-28(20)21-10-12-29-22(27-21)19(14-25-29)23(31)26-17-6-8-18(30)9-7-17/h1,3-4,10,12-14,17-18,20,30H,2,5-9,11H2,(H,26,31)/t17-,18-,20-/m1/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma, Inc.
US Patent
| Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ... |
US Patent US9782415 (2017)
BindingDB Entry DOI: 10.7270/Q2P84F0G |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM127662
(US10251889, Example 35 | US10758542, Example 35 | ...)Show SMILES O[C@H]1CC[C@@H](CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cccc(F)c1 |r,wU:4.7,wD:23.27,1.0,(6,-6.59,;5.6,-5.1,;6.69,-4.01,;6.29,-2.52,;4.81,-2.12,;3.72,-3.21,;4.12,-4.7,;4.41,-.64,;2.92,-.24,;1.83,-1.33,;2.52,1.25,;3.43,2.5,;2.52,3.74,;1.06,3.27,;-.28,4.04,;-1.61,3.27,;-1.61,1.73,;-.28,.96,;1.06,1.73,;-2.94,.96,;-2.94,-.58,;-4.41,-1.06,;-5.31,.19,;-4.41,1.43,;-4.81,2.92,;-6.29,3.32,;-6.69,4.81,;-5.6,5.9,;-4.12,5.5,;-3.03,6.59,;-3.72,4.01,)| Show InChI InChI=1S/C23H26FN5O2/c24-16-4-1-3-15(13-16)20-5-2-11-28(20)21-10-12-29-22(27-21)19(14-25-29)23(31)26-17-6-8-18(30)9-7-17/h1,3-4,10,12-14,17-18,20,30H,2,5-9,11H2,(H,26,31)/t17-,18-,20-/m1/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma Inc.
US Patent
| Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ... |
US Patent US10758542 (2020)
BindingDB Entry DOI: 10.7270/Q2RB77PD |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM127662
(US10251889, Example 35 | US10758542, Example 35 | ...)Show SMILES O[C@H]1CC[C@@H](CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cccc(F)c1 |r,wU:4.7,wD:23.27,1.0,(6,-6.59,;5.6,-5.1,;6.69,-4.01,;6.29,-2.52,;4.81,-2.12,;3.72,-3.21,;4.12,-4.7,;4.41,-.64,;2.92,-.24,;1.83,-1.33,;2.52,1.25,;3.43,2.5,;2.52,3.74,;1.06,3.27,;-.28,4.04,;-1.61,3.27,;-1.61,1.73,;-.28,.96,;1.06,1.73,;-2.94,.96,;-2.94,-.58,;-4.41,-1.06,;-5.31,.19,;-4.41,1.43,;-4.81,2.92,;-6.29,3.32,;-6.69,4.81,;-5.6,5.9,;-4.12,5.5,;-3.03,6.59,;-3.72,4.01,)| Show InChI InChI=1S/C23H26FN5O2/c24-16-4-1-3-15(13-16)20-5-2-11-28(20)21-10-12-29-22(27-21)19(14-25-29)23(31)26-17-6-8-18(30)9-7-17/h1,3-4,10,12-14,17-18,20,30H,2,5-9,11H2,(H,26,31)/t17-,18-,20-/m1/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 1.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Array BioPharma, Inc.
US Patent
| Assay Description Trk enzymatic selectivity was assessed using Omnia™ Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) an... |
US Patent US9796724 (2017)
BindingDB Entry DOI: 10.7270/Q27M0B21 |
More data for this Ligand-Target Pair | |
High affinity nerve growth factor receptor
(Homo sapiens (Human)) | BDBM127662
(US10251889, Example 35 | US10758542, Example 35 | ...)Show SMILES O[C@H]1CC[C@@H](CC1)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cccc(F)c1 |r,wU:4.7,wD:23.27,1.0,(6,-6.59,;5.6,-5.1,;6.69,-4.01,;6.29,-2.52,;4.81,-2.12,;3.72,-3.21,;4.12,-4.7,;4.41,-.64,;2.92,-.24,;1.83,-1.33,;2.52,1.25,;3.43,2.5,;2.52,3.74,;1.06,3.27,;-.28,4.04,;-1.61,3.27,;-1.61,1.73,;-.28,.96,;1.06,1.73,;-2.94,.96,;-2.94,-.58,;-4.41,-1.06,;-5.31,.19,;-4.41,1.43,;-4.81,2.92,;-6.29,3.32,;-6.69,4.81,;-5.6,5.9,;-4.12,5.5,;-3.03,6.59,;-3.72,4.01,)| Show InChI InChI=1S/C23H26FN5O2/c24-16-4-1-3-15(13-16)20-5-2-11-28(20)21-10-12-29-22(27-21)19(14-25-29)23(31)26-17-6-8-18(30)9-7-17/h1,3-4,10,12-14,17-18,20,30H,2,5-9,11H2,(H,26,31)/t17-,18-,20-/m1/s1 | PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
Similars
| US Patent
| n/a | n/a | 278 | n/a | n/a | n/a | n/a | n/a | n/a |
St. Jude Research Hospital
| Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ... |
J Med Chem 50: 1876-85 (2007)
BindingDB Entry DOI: 10.7270/Q2R49T22 |
More data for this Ligand-Target Pair | |