Compile Data Set for Download or QSAR

Found 5 hits Enz. Inhib. hit(s) with Target = 'High affinity nerve growth factor receptor' and Ligand = 'BDBM127781'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM127781 (US10251889, Example 154 | US10758542, Example 154 ...) Show SMILES COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)N[C@H]3CC[C@H](O)C3)c2n1 |r| Show InChI InChI=1S/C22H25FN6O3/c1-32-22-16(9-13(23)11-24-22)18-3-2-7-28(18)19-6-8-29-20(27-19)17(12-25-29)21(31)26-14-4-5-15(30)10-14/h6,8-9,11-12,14-15,18,30H,2-5,7,10H2,1H3,(H,26,31)/t14-,15-,18+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	7.5	n/a
Array Biopharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US8791123 (2014) BindingDB Entry DOI: 10.7270/Q2Q23XX7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM127781 (US10251889, Example 154 | US10758542, Example 154 ...) Show SMILES COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)N[C@H]3CC[C@H](O)C3)c2n1 |r| Show InChI InChI=1S/C22H25FN6O3/c1-32-22-16(9-13(23)11-24-22)18-3-2-7-28(18)19-6-8-29-20(27-19)17(12-25-29)21(31)26-14-4-5-15(30)10-14/h6,8-9,11-12,14-15,18,30H,2-5,7,10H2,1H3,(H,26,31)/t14-,15-,18+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US9782415 (2017) BindingDB Entry DOI: 10.7270/Q2P84F0G
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM127781 (US10251889, Example 154 | US10758542, Example 154 ...) Show SMILES COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)N[C@H]3CC[C@H](O)C3)c2n1 |r| Show InChI InChI=1S/C22H25FN6O3/c1-32-22-16(9-13(23)11-24-22)18-3-2-7-28(18)19-6-8-29-20(27-19)17(12-25-29)21(31)26-14-4-5-15(30)10-14/h6,8-9,11-12,14-15,18,30H,2-5,7,10H2,1H3,(H,26,31)/t14-,15-,18+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US10758542 (2020) BindingDB Entry DOI: 10.7270/Q2RB77PD
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM127781 (US10251889, Example 154 | US10758542, Example 154 ...) Show SMILES COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)N[C@H]3CC[C@H](O)C3)c2n1 |r| Show InChI InChI=1S/C22H25FN6O3/c1-32-22-16(9-13(23)11-24-22)18-3-2-7-28(18)19-6-8-29-20(27-19)17(12-25-29)21(31)26-14-4-5-15(30)10-14/h6,8-9,11-12,14-15,18,30H,2-5,7,10H2,1H3,(H,26,31)/t14-,15-,18+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Array BioPharma, Inc. US Patent					Assay Description Trk enzymatic selectivity was assessed using Omnia™ Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) an...				US Patent US9796724 (2017) BindingDB Entry DOI: 10.7270/Q27M0B21
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM127781 (US10251889, Example 154 | US10758542, Example 154 ...) Show SMILES COc1ncc(F)cc1[C@H]1CCCN1c1ccn2ncc(C(=O)N[C@H]3CC[C@H](O)C3)c2n1 |r| Show InChI InChI=1S/C22H25FN6O3/c1-32-22-16(9-13(23)11-24-22)18-3-2-7-28(18)19-6-8-29-20(27-19)17(12-25-29)21(31)26-14-4-5-15(30)10-14/h6,8-9,11-12,14-15,18,30H,2-5,7,10H2,1H3,(H,26,31)/t14-,15-,18+/m0/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	524	n/a	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q2R49T22
					More data for this Ligand-Target Pair