Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'High affinity nerve growth factor receptor' and Ligand = 'BDBM134633'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM134633 (US8846698, 96) Show SMILES CC(C)n1cc(C(=O)c2cncc(NC(=O)Cn3nc(cc3C)C(F)(F)F)c2)c2cncnc12 Show InChI InChI=1S/C22H20F3N7O2/c1-12(2)31-9-17(16-8-27-11-28-21(16)31)20(34)14-5-15(7-26-6-14)29-19(33)10-32-13(3)4-18(30-32)22(23,24)25/h4-9,11-12H,10H2,1-3H3,(H,29,33)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.45	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Limited US Patent					Assay Description Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...				US Patent US8846698 (2014) BindingDB Entry DOI: 10.7270/Q2F47MTW
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