Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'High affinity nerve growth factor receptor' and Ligand = 'BDBM135069'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM135069 (US8846698, 556) Show SMILES Cc1ccc(CC(=O)Nc2cncc(c2)C(=O)c2cn(c3nc(N)ncc23)C(C)(C)CO)nc1 Show InChI InChI=1S/C24H25N7O3/c1-14-4-5-16(27-8-14)7-20(33)29-17-6-15(9-26-10-17)21(34)19-12-31(24(2,3)13-32)22-18(19)11-28-23(25)30-22/h4-6,8-12,32H,7,13H2,1-3H3,(H,29,33)(H2,25,28,30)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.16	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Limited US Patent					Assay Description Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...				US Patent US8846698 (2014) BindingDB Entry DOI: 10.7270/Q2F47MTW
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