Compile Data Set for Download or QSAR

Found 5 hits Enz. Inhib. hit(s) with Target = 'High affinity nerve growth factor receptor' and Ligand = 'BDBM136682'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136682 (US10005783, 99 | US10047097, 99 | US10774085, Exam...) Show SMILES NC(=O)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C18H16F2N6O2/c19-10-3-4-12(20)11(8-10)14-2-1-6-25(14)15-5-7-26-17(24-15)13(9-22-26)23-18(28)16(21)27/h3-5,7-9,14H,1-2,6H2,(H2,21,27)(H,23,28)/t14-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.65	n/a	n/a	n/a	n/a	7.5	n/a
Array BioPharma Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US8865698 (2014) BindingDB Entry DOI: 10.7270/Q2B856TM
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136682 (US10005783, 99 | US10047097, 99 | US10774085, Exam...) Show SMILES NC(=O)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C18H16F2N6O2/c19-10-3-4-12(20)11(8-10)14-2-1-6-25(14)15-5-7-26-17(24-15)13(9-22-26)23-18(28)16(21)27/h3-5,7-9,14H,1-2,6H2,(H2,21,27)(H,23,28)/t14-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.65	n/a	n/a	n/a	n/a	7.5	n/a
Array BioPharma Inc. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US10047097 (2018) BindingDB Entry DOI: 10.7270/Q2000442
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136682 (US10005783, 99 | US10047097, 99 | US10774085, Exam...) Show SMILES NC(=O)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C18H16F2N6O2/c19-10-3-4-12(20)11(8-10)14-2-1-6-25(14)15-5-7-26-17(24-15)13(9-22-26)23-18(28)16(21)27/h3-5,7-9,14H,1-2,6H2,(H2,21,27)(H,23,28)/t14-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.65	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				Citation and Details BindingDB Entry DOI: 10.7270/Q24M97R7
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136682 (US10005783, 99 | US10047097, 99 | US10774085, Exam...) Show SMILES NC(=O)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C18H16F2N6O2/c19-10-3-4-12(20)11(8-10)14-2-1-6-25(14)15-5-7-26-17(24-15)13(9-22-26)23-18(28)16(21)27/h3-5,7-9,14H,1-2,6H2,(H2,21,27)(H,23,28)/t14-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.65	n/a	n/a	n/a	n/a	n/a	n/a
ARRAY BIOPHARMA INC. US Patent					Assay Description An enzyme-linked immunosorbant assay (ELISA) was used to assess TrkA kinase activity in the presence of inhibitors. Immulon 4HBX 384-well microtiter ...				US Patent US10774085 (2020) BindingDB Entry DOI: 10.7270/Q2862KHP
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM136682 (US10005783, 99 | US10047097, 99 | US10774085, Exam...) Show SMILES NC(=O)C(=O)Nc1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)ccc1F |r| Show InChI InChI=1S/C18H16F2N6O2/c19-10-3-4-12(20)11(8-10)14-2-1-6-25(14)15-5-7-26-17(24-15)13(9-22-26)23-18(28)16(21)27/h3-5,7-9,14H,1-2,6H2,(H2,21,27)(H,23,28)/t14-/m1/s1	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.65	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research					Assay Description Trk enzymatic selectivity was assessed using Omnia Kinase Assay reagents from Invitrogen Corp. Enzyme (either TrkA or TrkB from Invitrogen Corp.) and...				Bioorg Med Chem 17: 7802-15 (2009) BindingDB Entry DOI: 10.7270/Q25H7JK7
					More data for this Ligand-Target Pair