Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'High affinity nerve growth factor receptor' and Ligand = 'BDBM186344'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM186344 (US9163021, 1) Show SMILES Cc1cc(nn1CC(=O)Nc1cncc(c1)C(=O)c1cn(c2c(F)cncc12)C(C)(C)CO)C(F)(F)F Show InChI InChI=1S/C24H22F4N6O3/c1-13-4-19(24(26,27)28)32-34(13)11-20(36)31-15-5-14(6-29-7-15)22(37)17-10-33(23(2,3)12-35)21-16(17)8-30-9-18(21)25/h4-10,35H,11-12H2,1-3H3,(H,31,36)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.32	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Limited US Patent					Assay Description Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...				US Patent US9163021 (2015) BindingDB Entry DOI: 10.7270/Q29C6W7C
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