Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'High affinity nerve growth factor receptor' and Ligand = 'BDBM186345'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM186345 (US9163021, 2) Show SMILES CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cn3ccc(n3)C3CC3)c2)c2cncc(F)c12 Show InChI InChI=1S/C25H25FN6O3/c1-25(2,14-33)32-12-19(18-10-28-11-20(26)23(18)32)24(35)16-7-17(9-27-8-16)29-22(34)13-31-6-5-21(30-31)15-3-4-15/h5-12,15,33H,3-4,13-14H2,1-2H3,(H,29,34)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.58	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Limited US Patent					Assay Description Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...				US Patent US9163021 (2015) BindingDB Entry DOI: 10.7270/Q29C6W7C
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