Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'High affinity nerve growth factor receptor' and Ligand = 'BDBM186357'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM186357 (US9163021, 14) Show SMILES CC(C)c1cn(CC(=O)Nc2cncc(c2)C(=O)c2cn(c3ccncc23)C(C)(C)CO)nn1 Show InChI InChI=1S/C24H27N7O3/c1-15(2)20-12-30(29-28-20)13-22(33)27-17-7-16(8-26-9-17)23(34)19-11-31(24(3,4)14-32)21-5-6-25-10-18(19)21/h5-12,15,32H,13-14H2,1-4H3,(H,27,33)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	9.89	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Limited US Patent					Assay Description Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...				US Patent US9163021 (2015) BindingDB Entry DOI: 10.7270/Q29C6W7C
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