Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'High affinity nerve growth factor receptor' and Ligand = 'BDBM186358'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM186358 (US9163021, 15) Show SMILES CC(C)(CO)n1cc(C(=O)c2cncc(NC(=O)Cn3cc(nn3)C3CC3)c2)c2cnccc12 Show InChI InChI=1S/C24H25N7O3/c1-24(2,14-32)31-11-19(18-10-25-6-5-21(18)31)23(34)16-7-17(9-26-8-16)27-22(33)13-30-12-20(28-29-30)15-3-4-15/h5-12,15,32H,3-4,13-14H2,1-2H3,(H,27,33)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12.4	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Limited US Patent					Assay Description Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...				US Patent US9163021 (2015) BindingDB Entry DOI: 10.7270/Q29C6W7C
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