Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'High affinity nerve growth factor receptor' and Ligand = 'BDBM186500'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM186500 (US9163021, 163) Show SMILES CC(C)n1cc(C(=O)c2ccnc(NC(=O)Cn3cc(nn3)C(F)(F)F)c2)c2cnccc12 Show InChI InChI=1S/C21H18F3N7O2/c1-12(2)31-9-15(14-8-25-5-4-16(14)31)20(33)13-3-6-26-18(7-13)27-19(32)11-30-10-17(28-29-30)21(22,23)24/h3-10,12H,11H2,1-2H3,(H,26,27,32)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10.7	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Limited US Patent					Assay Description Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...				US Patent US9163021 (2015) BindingDB Entry DOI: 10.7270/Q29C6W7C
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