Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'High affinity nerve growth factor receptor' and Ligand = 'BDBM186521'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM186521 (US9163021, 186) Show SMILES CC(C)n1cc(C(=O)c2ccnc(NC(=O)Cc3ccc(F)cc3)c2)c2cnccc12 Show InChI InChI=1S/C24H21FN4O2/c1-15(2)29-14-20(19-13-26-9-8-21(19)29)24(31)17-7-10-27-22(12-17)28-23(30)11-16-3-5-18(25)6-4-16/h3-10,12-15H,11H2,1-2H3,(H,27,28,30)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13.3	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Limited US Patent					Assay Description Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...				US Patent US9163021 (2015) BindingDB Entry DOI: 10.7270/Q29C6W7C
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