Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'High affinity nerve growth factor receptor' and Ligand = 'BDBM186522'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM186522 (US9163021, 189) Show SMILES CC(C)n1cc(C(=O)c2ccnc(NC(=O)Cc3coc(n3)C3CC3)c2)c2cnccc12 Show InChI InChI=1S/C24H23N5O3/c1-14(2)29-12-19(18-11-25-7-6-20(18)29)23(31)16-5-8-26-21(9-16)28-22(30)10-17-13-32-24(27-17)15-3-4-15/h5-9,11-15H,3-4,10H2,1-2H3,(H,26,28,30)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13.6	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Limited US Patent					Assay Description Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...				US Patent US9163021 (2015) BindingDB Entry DOI: 10.7270/Q29C6W7C
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