Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'High affinity nerve growth factor receptor' and Ligand = 'BDBM186527'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM186527 (US9163021, 194) Show SMILES FC(F)(F)Oc1cccc(CC(=O)Nc2cc(ccn2)C(=O)c2cn(C3COC3)c3ccncc23)c1 Show InChI InChI=1S/C25H19F3N4O4/c26-25(27,28)36-18-3-1-2-15(8-18)9-23(33)31-22-10-16(4-7-30-22)24(34)20-12-32(17-13-35-14-17)21-5-6-29-11-19(20)21/h1-8,10-12,17H,9,13-14H2,(H,30,31,33)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13.8	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Limited US Patent					Assay Description Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat#62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor sou...				US Patent US9163021 (2015) BindingDB Entry DOI: 10.7270/Q29C6W7C
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