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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'High affinity nerve growth factor receptor' and Ligand = 'BDBM226348'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM226348
PNG
(US9328096, 41)
Show SMILES CC(C)(O)CNC(=O)c1cc(NC(=O)c2cc(c(F)cc2Cl)-c2ncccc2F)n(n1)-c1ccccc1
Show InChI InChI=1S/C26H22ClF2N5O3/c1-26(2,37)14-31-25(36)21-13-22(34(33-21)15-7-4-3-5-8-15)32-24(35)16-11-17(20(29)12-18(16)27)23-19(28)9-6-10-30-23/h3-13,37H,14H2,1-2H3,(H,31,36)(H,32,35)
PDB
MMDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 23n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at prolink-tagged TrkA (unknown origin) expressed in cells assessed as inhibition of NGF-induced receptor phosphorylation by meas...

J Med Chem 62: 247-265 (2019)


Article DOI: 10.1021/acs.jmedchem.8b00280
BindingDB Entry DOI: 10.7270/Q2QR51CZ
More data for this
Ligand-Target Pair