Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'High affinity nerve growth factor receptor' and Ligand = 'BDBM356068'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM356068 (2-fluoro-5-(1-methyl-1H- pyrazol-3-yl)-N-(2-((2- (...) Show SMILES Cn1ccc(n1)-c1cc(C(=O)Nc2cnc(CNC(=O)Cn3cncn3)nc2-c2ccccc2)c(F)cc1C(F)(F)F Show InChI InChI=1S/C27H21F4N9O2/c1-39-8-7-21(38-39)17-9-18(20(28)10-19(17)27(29,30)31)26(42)36-22-11-33-23(37-25(22)16-5-3-2-4-6-16)12-34-24(41)13-40-15-32-14-35-40/h2-11,14-15H,12-13H2,1H3,(H,34,41)(H,36,42)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...				US Patent US9815846 (2017) BindingDB Entry DOI: 10.7270/Q20P129R
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