Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'High affinity nerve growth factor receptor' and Ligand = 'BDBM356198'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM356198 (US9815846, Compound 198) Show SMILES Cn1ccc(n1)-c1cc(C(=O)Nc2ccc(nc2-c2ccccc2)C2CNC(=O)C2)c(F)cc1C(F)(F)F Show InChI InChI=1S/C27H21F4N5O2/c1-36-10-9-22(35-36)17-12-18(20(28)13-19(17)27(29,30)31)26(38)34-23-8-7-21(16-11-24(37)32-14-16)33-25(23)15-5-3-2-4-6-15/h2-10,12-13,16H,11,14H2,1H3,(H,32,37)(H,34,38)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.570	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...				US Patent US9815846 (2017) BindingDB Entry DOI: 10.7270/Q20P129R
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