Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'High affinity nerve growth factor receptor' and Ligand = 'BDBM374719'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM374719 (11-fluoro-14-(propan-2-yl)-6,7,13,14-tetrahydro- 1...) Show SMILES CC(C)N1Cc2cc(F)ccc2OCCNC(=O)c2cnn3ccc1nc23 Show InChI InChI=1S/C19H20FN5O2/c1-12(2)24-11-13-9-14(20)3-4-16(13)27-8-6-21-19(26)15-10-22-25-7-5-17(24)23-18(15)25/h3-5,7,9-10,12H,6,8,11H2,1-2H3,(H,21,26)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.0820	n/a	n/a	n/a	n/a	n/a
Turning Point Therapeutics, Inc. US Patent					Assay Description Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...				US Patent US10618912 (2020) BindingDB Entry DOI: 10.7270/Q2SN0D08
					More data for this Ligand-Target Pair
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM374719 (11-fluoro-14-(propan-2-yl)-6,7,13,14-tetrahydro- 1...) Show SMILES CC(C)N1Cc2cc(F)ccc2OCCNC(=O)c2cnn3ccc1nc23 Show InChI InChI=1S/C19H20FN5O2/c1-12(2)24-11-13-9-14(20)3-4-16(13)27-8-6-21-19(26)15-10-22-25-7-5-17(24)23-18(15)25/h3-5,7,9-10,12H,6,8,11H2,1-2H3,(H,21,26)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	0.0820	n/a	n/a	n/a	n/a	n/a
St. Jude Research Hospital					Assay Description Kinase binding assays were performed at DiscoveRx using the general KINOMEscan Kd Protocol (Fabian, M. A. et al., “A small molecule-kinase interactio...				J Med Chem 50: 1876-85 (2007) BindingDB Entry DOI: 10.7270/Q20P12B6
					More data for this Ligand-Target Pair