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Found 1 hit Enz. Inhib. hit(s) with Target = 'High affinity nerve growth factor receptor' and Ligand = 'BDBM50498449'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
High affinity nerve growth factor receptor


(Homo sapiens (Human))		BDBM50498449
PNG
(CHEMBL3596889)
Show SMILES CC(C)(C)c1cc(NC(=O)Nc2cccc(Oc3cncc(n3)-c3ccc(F)cc3)c2)no1
Show InChI InChI=1S/C24H22FN5O3/c1-24(2,3)20-12-21(30-33-20)29-23(31)27-17-5-4-6-18(11-17)32-22-14-26-13-19(28-22)15-7-9-16(25)10-8-15/h4-14H,1-3H3,(H2,27,29,30,31)
PDB
MMDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 22n/an/an/an/an/an/a



The University of Arizona

Curated by ChEMBL


Assay Description
Inhibition of human recombinant TrkA using ATP and 5FAM tagged TrkA peptide substrate incubated for 60 mins by microfluidics assay

Medchemcomm 5: 1507-1514 (2014)


Article DOI: 10.1039/c4md00251b
BindingDB Entry DOI: 10.7270/Q2WW7MQ5
More data for this
Ligand-Target Pair