Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histamine H4 receptor (Homo sapiens (Human)) | BDBM50509065 (CHEMBL4439142) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Regensburg Curated by ChEMBL | Assay Description Displacement of 10 nM [3H]-histamine from human H4R expressed in Sf9 cell membranes co-expressing Gia2 and beta1gamma2 by competition binding assay | J Med Chem 62: 8338-8356 (2019) Article DOI: 10.1021/acs.jmedchem.9b01342 BindingDB Entry DOI: 10.7270/Q28K7DCH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H4 receptor (Rattus norvegicus (rat)) | BDBM50509065 (CHEMBL4439142) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 26 | n/a | n/a | n/a | n/a |
University of Regensburg Curated by ChEMBL | Assay Description Agonist activity at rat H4R expressed in HEK293T-beta-arr2-rH4R cells by beta-arrestin2 recruitment assay | J Med Chem 62: 8338-8356 (2019) Article DOI: 10.1021/acs.jmedchem.9b01342 BindingDB Entry DOI: 10.7270/Q28K7DCH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H4 receptor (Rattus norvegicus (rat)) | BDBM50509065 (CHEMBL4439142) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 0.646 | n/a | n/a | n/a | n/a |
University of Regensburg Curated by ChEMBL | Assay Description Agonist activity at rat H4R expressed in HEK293-SF-rH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay | J Med Chem 62: 8338-8356 (2019) Article DOI: 10.1021/acs.jmedchem.9b01342 BindingDB Entry DOI: 10.7270/Q28K7DCH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H4 receptor (Homo sapiens (Human)) | BDBM50509065 (CHEMBL4439142) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a |
University of Regensburg Curated by ChEMBL | Assay Description Agonist activity at human H4R expressed in HEK293-SF-hH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay | J Med Chem 62: 8338-8356 (2019) Article DOI: 10.1021/acs.jmedchem.9b01342 BindingDB Entry DOI: 10.7270/Q28K7DCH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H4 receptor (Mus musculus (mouse)) | BDBM50509065 (CHEMBL4439142) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 51 | n/a | n/a | n/a | n/a |
University of Regensburg Curated by ChEMBL | Assay Description Agonist activity at mouse H4R expressed in HEK293T-beta-arr2-mH4R cells by beta-arrestin2 recruitment assay | J Med Chem 62: 8338-8356 (2019) Article DOI: 10.1021/acs.jmedchem.9b01342 BindingDB Entry DOI: 10.7270/Q28K7DCH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H4 receptor (Homo sapiens (Human)) | BDBM50509065 (CHEMBL4439142) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 19 | n/a | n/a | n/a | n/a |
University of Regensburg Curated by ChEMBL | Assay Description Agonist activity at human H4R expressed in HEK293T-beta-arr2-hH4R cells by beta-arrestin2 recruitment assay | J Med Chem 62: 8338-8356 (2019) Article DOI: 10.1021/acs.jmedchem.9b01342 BindingDB Entry DOI: 10.7270/Q28K7DCH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histamine H4 receptor (Mus musculus (mouse)) | BDBM50509065 (CHEMBL4439142) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 1 | n/a | n/a | n/a | n/a |
University of Regensburg Curated by ChEMBL | Assay Description Agonist activity at mouse H4R expressed in HEK293-SF-mH4R-His6-CRE-Luc cells incubated for 5 hrs by luciferase reporter gene assay | J Med Chem 62: 8338-8356 (2019) Article DOI: 10.1021/acs.jmedchem.9b01342 BindingDB Entry DOI: 10.7270/Q28K7DCH | |||||||||||
More data for this Ligand-Target Pair |