Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histone acetyltransferase p300 (Homo sapiens (Human)) | BDBM50140172 (CHEBI:3962 | CHEMBL140 | Curcumin | US9409845, Tab...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 6.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Freiburg Curated by ChEMBL | Assay Description Inhibition of recombinant human p300 catalytic domain (1284 to 1673 residues) using histone H3 peptide substrate after 1 hr by liquid scintillation c... | J Med Chem 59: 1249-70 (2016) Article DOI: 10.1021/acs.jmedchem.5b01502 BindingDB Entry DOI: 10.7270/Q2DV1MRN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone acetyltransferase p300 (Homo sapiens (Human)) | BDBM50140172 (CHEBI:3962 | CHEMBL140 | Curcumin | US9409845, Tab...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences Curated by ChEMBL | Assay Description Inhibition of recombinant human full-length His6-tagged p300 expressed in baculovirus infected Sf21 insect cells using [3H]acetylCoA as substrate pre... | J Med Chem 63: 1337-1360 (2020) Article DOI: 10.1021/acs.jmedchem.9b01721 BindingDB Entry DOI: 10.7270/Q25Q50C7 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone acetyltransferase p300 (Homo sapiens (Human)) | BDBM50140172 (CHEBI:3962 | CHEMBL140 | Curcumin | US9409845, Tab...) | PDB MMDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Freiburg Curated by ChEMBL | Assay Description Inhibition of recombinant p300 (unknown origin) expressed in baculovirus expression system using histone substrate after 10 mins by liquid scintillat... | J Med Chem 59: 1249-70 (2016) Article DOI: 10.1021/acs.jmedchem.5b01502 BindingDB Entry DOI: 10.7270/Q2DV1MRN | |||||||||||
More data for this Ligand-Target Pair |